Product image of Mikafungin Teva (Micafungin) supplied by GNH India

Mikafungin Teva

Active Ingredient:
Micafungin
Origin:
EU

Mikafungin Teva (Micafungin)

Micafungin, the active ingredient in Mikafungin Teva, is an echinocandin antifungal presented as an intravenous solution for intravenous use. It treats invasive fungal infections such as candidemia, esophageal candidiasis, and is used for prophylaxis in hematopoietic stem cell transplantation patients.

GNH India supplies Mikafungin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Mikafungin Teva is an echinocandin antifungal indicated for several serious fungal infections.

  • Invasive candidiasis: treatment of systemic Candida infection in immunocompromised patients.
  • Esophageal candidiasis: eradication of Candida infection of the esophagus.
  • Candidemia: clearance of Candida species from the bloodstream.
  • Prophylaxis of fungal infections in hematopoietic stem cell transplantation: prevention of invasive fungal disease in transplant recipients.

How It Works

  • Micafungin inhibits the enzyme β-(1,3)-D-glucan synthase, which is essential for synthesizing β-(1,3)-D-glucan, a key structural component of the fungal cell wall. By disrupting cell wall formation, the drug exerts a fungicidal effect against susceptible Candida and Aspergillus species, leading to cell lysis and death.

Side Effects

Mikafungin Teva may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Fever: transient temperature rise during infusion.
  • Nausea: mild gastrointestinal upset.
  • Elevated liver enzymes: transient increase in ALT/AST.
  • Infusion‑related reactions: flushing, rash, or mild hypotension.

Serious or Rare Side Effects

  • Hepatic failure: severe liver injury requiring monitoring.
  • Severe hypersensitivity: anaphylactic reactions that may be life‑threatening.
  • Renal dysfunction: acute kidney injury in susceptible patients.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Liver function monitoring: check ALT/AST before and during treatment.
  • Renal function assessment: evaluate creatinine clearance prior to use.
  • Hypersensitivity screening: discontinue if signs of allergic reaction appear.
  • Drug interaction review: assess concomitant medications that may affect micafungin metabolism.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Micafungin can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Cyclosporine: increased micafungin exposure may require dose adjustment.
  • Rifampin: decreased micafungin levels can reduce antifungal effectiveness.

Moderate Interactions (Monitor Closely)

  • Azole antifungals (e.g., fluconazole): potential additive hepatotoxicity.
  • Warfarin: possible alteration of INR; monitor coagulation parameters.
  • Statins (e.g., simvastatin): increased risk of myopathy; monitor creatine kinase levels.

Frequently Asked Questions

Mikafungin Teva is an intravenous echinocandin antifungal indicated for the treatment of invasive candidiasis, esophageal candidiasis, candidemia, and for prophylaxis of fungal infections in patients undergoing hematopoietic stem cell transplantation.

Micafungin inhibits the fungal enzyme β-(1,3)-D-glucan synthase, blocking the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall. This disruption weakens the wall, leading to cell lysis and death of susceptible fungi.

The dose of Mikafungin Teva is determined by the prescribing clinician based on the specific infection, patient weight, renal and hepatic function, and treatment setting. Exact dosing regimens are individualized and should follow local clinical guidelines.

Safety data for micafungin in pregnancy and lactation are limited. The product is classified as pregnancy category unknown, and use should be considered only if the potential benefit justifies the potential risk to the fetus or infant. Consultation with a specialist is recommended.

To order Mikafungin Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Mikafungin belongs to the echinocandin class, which targets the fungal cell wall, unlike azoles that inhibit ergosterol synthesis or polyenes that bind membrane sterols. Echinocandins generally have a favorable safety profile and are effective against many Candida species, including those resistant to azoles.

Mikafungin Teva should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. The vial should remain in its original packaging until use to maintain stability.

Mikafungin Teva is administered as an intravenous infusion over a period specified by the prescriber, typically 30‑60 minutes. The infusion should be given through a suitable IV line using aseptic technique, and the dosage is adjusted according to clinical response and patient factors.

Serious risks include hepatic failure, severe hypersensitivity reactions such as anaphylaxis, and renal dysfunction. Patients should be monitored for signs of liver injury, allergic reactions, and changes in kidney function throughout therapy.

Mikafungin Teva should be avoided in patients with known hypersensitivity to micafungin or any component of the formulation. Caution is also advised for individuals with severe hepatic impairment, as safety has not been fully established in this population.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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