Product image of Mikofenolsav Tillomed (Mycophenolic Acid) supplied by GNH India

Mikofenolsav Tillomed

Active Ingredient:
Mycophenolic Acid
Origin:
EU

Mikofenolsav Tillomed (Mycophenolic Acid)

Mycophenolic Acid, the active ingredient in Mikofenolsav Tillomed, is an antimetabolite immunosuppressant presented as an oral formulation for systemic use. It is used to prevent organ transplant rejection and to treat lupus nephritis in appropriate patients.

GNH India supplies Mikofenolsav Tillomed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Manufacturer / TM Owner

Tillomed Malta Ltd

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Indications & Clinical Uses

Mycophenolic Acid is employed in immunosuppressive therapy to control immune‑mediated processes.

  • Organ transplant rejection: helps prevent graft rejection by suppressing lymphocyte proliferation.
  • Lupus nephritis: reduces renal inflammation in systemic lupus erythematosus.
  • Kidney transplant: supports long‑term graft survival by inhibiting T‑ and B‑cell activation.

How It Works

  • Mycophenolic Acid inhibits inosine monophosphate dehydrogenase (IMPDH), the key enzyme for guanosine nucleotide synthesis. By limiting guanosine pools, it selectively impairs proliferation of activated T and B lymphocytes, thereby dampening the adaptive immune response that drives transplant rejection and autoimmune kidney injury.

Side Effects

Mycophenolic Acid may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, vomiting, diarrhea.
  • Hematologic changes: anemia, leukopenia, thrombocytopenia.
  • Infections: increased susceptibility to bacterial, viral or fungal infections.
  • Headache or dizziness.

Serious or Rare Side Effects

  • Severe neutropenia or agranulocytosis.
  • Opportunistic infections such as Pneumocystis jirovecii pneumonia.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.

Precautions & Warnings

Patients should be monitored regularly for safety and efficacy.

  • Monitor blood counts: perform complete blood count before therapy and periodically thereafter.
  • Assess renal function: adjust therapy if creatinine clearance declines.
  • Screen for infections: evaluate for active viral or bacterial infections prior to initiation.
  • Avoid live vaccines: immunosuppression may reduce vaccine efficacy and increase risk.
  • Pregnancy and lactation: discuss risks with a healthcare professional before use.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mycophenolic Acid can interact with several drug classes, altering its exposure or increasing toxicity.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce absorption of mycophenolic acid.
  • Azathioprine: additive bone‑marrow suppression.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly decrease drug levels.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (ketoconazole, fluconazole): may increase mycophenolic acid concentrations.
  • ACE inhibitors or ARBs: combined use may worsen renal function.
  • Vaccines: live attenuated vaccines should be avoided during therapy.

Frequently Asked Questions

Mikofenolsav Tillomed contains mycophenolic acid, an antimetabolite immunosuppressant used primarily to prevent rejection of transplanted organs and to treat lupus nephritis, a kidney manifestation of systemic lupus erythematosus.

Mycophenolic acid blocks the enzyme inosine monophosphate dehydrogenase, which is essential for making guanosine nucleotides. This inhibition limits the proliferation of activated T and B lymphocytes, thereby reducing the immune response that can damage transplanted tissue or inflamed kidneys.

The specific dose of Mikofenolsav Tillomed is determined by the prescribing clinician based on the patient’s condition, weight, renal function and other individual factors. Only a qualified healthcare professional should set the dosing regimen.

The safety of mycophenolic acid in pregnancy and lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks with their physician before using this medication.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mycophenolic acid differs from calcineurin inhibitors such as cyclosporine or tacrolimus by targeting nucleotide synthesis rather than calcium‑dependent signaling. This distinct mechanism can offer a complementary safety profile, but the choice of therapy depends on the transplant protocol, patient tolerance and physician judgment.

Store Mikofenolsav Tillomed at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, heat and direct sunlight, and ensure the container is tightly closed when not in use.

Mikofenolsav Tillomed is taken orally, usually with food or a glass of water to improve tolerability. The exact administration schedule, including timing relative to other medications, should follow the prescribing clinician’s instructions.

Serious risks include severe bone‑marrow suppression (e.g., neutropenia, agranulocytosis), opportunistic infections such as Pneumocystis jirovecii pneumonia, and potential liver toxicity. Patients should be monitored regularly for blood count changes and signs of infection.

Mikofenolsav Tillomed is contraindicated in patients with known hypersensitivity to mycophenolic acid or any of its excipients, in those with active uncontrolled infections, and in individuals with severe renal impairment unless dose adjustments are made under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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