Product image of Milax 1,0 (Glycerol) supplied by GNH India

Milax 1,0

Active Ingredient:
Glycerol
Origin:
EU

Milax 1,0 (Glycerol)

Glycerol, the active ingredient in Milax 1,0, is an osmotic laxative presented as a suppository for rectal use. It is employed to soften stool and stimulate bowel movements in individuals experiencing constipation or fecal impaction, including adults and older children.

GNH India supplies Milax 1,0 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for each batch. This enables reliable procurement for diverse healthcare settings across Europe and beyond.

Manufacturer / TM Owner

Berlin-Chemie Ag

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Indications & Clinical Uses

  • Milax 1,0 (glycerol) acts as an osmotic laxative to relieve constipation and related bowel disorders.
  • Constipation: softens hardened stool and promotes regular bowel movements.
  • Fecal impaction: facilitates evacuation of impacted feces by increasing water content in the colon.
  • Post‑operative constipation: helps restore normal transit after surgical procedures when oral laxatives are unsuitable.

How It Works

  • Glycerol works by osmotically drawing water from the intestinal mucosa into the lumen of the rectum. The increased fluid volume softens the stool and expands the rectal walls, triggering stretch receptors that stimulate peristaltic activity. This local osmotic effect does not rely on systemic absorption, providing a rapid, targeted laxative action when administered as a suppository. The resulting lubrication also eases passage of the stool through the anal canal.

Side Effects

Glycerol suppositories may cause local and systemic reactions, most of which are mild and transient.

Common Side Effects

  • Rectal irritation: mild burning or discomfort at the application site.
  • Increased bowel frequency: loose stools or mild diarrhea.
  • Abdominal cramping: transient cramps following evacuation.

Serious or Rare Side Effects

  • Severe rectal bleeding: unexpected bleeding requiring medical attention.
  • Allergic reaction: rash, itching, or swelling indicating hypersensitivity.
  • Electrolyte imbalance: rare cases of significant fluid shifts leading to abnormal serum electrolytes.

Precautions & Warnings

  • Before using Milax 1,0, consider the following precautions to ensure safe and effective treatment.
  • Assess bowel obstruction: avoid use if a mechanical blockage is suspected.
  • Pregnancy and lactation: consult a healthcare professional before use, as safety data are limited.
  • Age considerations: use under medical supervision in children younger than 2 years.
  • Concurrent laxative therapy: do not combine with other osmotic or stimulant laxatives without guidance.
  • Allergy check: discontinue if signs of hypersensitivity appear.
  • Store at room temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Glycerol may interact with certain medications or conditions; awareness of these interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Concurrent use with strong stimulant laxatives: may cause excessive fluid loss and electrolyte disturbances.
  • Rectal administration of oil‑based medications: can impair absorption of glycerol.
  • Severe dehydration: glycerol may exacerbate fluid deficits.

Moderate Interactions (Monitor Closely)

  • Anticholinergic drugs: may reduce the efficacy of glycerol‑induced peristalsis.
  • Diuretics: monitor electrolyte balance when both are used.
  • Magnesium‑containing antacids: may increase osmotic load in the gut.

Frequently Asked Questions

Milax 1,0 is a glycerol‑based rectal suppository indicated for the relief of occasional constipation and for the management of fecal impaction. It works locally in the rectum to soften stool and promote evacuation, making it useful for adults and older children who need a fast‑acting, non‑oral laxative option.

Glycerol acts as an osmotic agent. When inserted rectally, it draws water from surrounding tissues into the intestinal lumen, increasing fluid volume. This softens the stool, expands the rectal walls, and activates stretch receptors that trigger peristaltic movements, facilitating a gentle and rapid bowel movement.

The appropriate dose of Milax 1,0 is determined by the prescribing healthcare professional based on the patient’s age, severity of constipation, and clinical response. The product is supplied as a single‑dose suppository, and the prescriber decides how many suppositories may be used and the interval between administrations.

Safety data for glycerol suppositories in pregnancy and lactation are limited. Women who are pregnant or breastfeeding should consult their physician before using Milax 1,0. The prescriber will weigh potential benefits against any uncertain risks to the mother and the infant.

To place an order, submit an enquiry on the Milax 1,0 product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing a quotation, availability, shipping details, and any necessary import documentation.

Milax 1,0 provides a local, rectal route of administration, which can be advantageous when oral intake is limited or rapid relief is needed. Unlike stimulant laxatives, glycerol works by osmotic water attraction, resulting in a gentler effect and a lower risk of cramping. It is also non‑systemic, reducing the likelihood of drug‑wide interactions.

Milax 1,0 should be stored at room temperature, ideally below 25 °C, in its original packaging to protect it from moisture and heat. Keep the product out of direct sunlight and away from sources of humidity to maintain its integrity and efficacy.

The suppository is inserted gently into the rectum, preferably after a light meal, using a gloved finger or applicator. The patient should remain lying down for a few minutes to allow the glycerol to melt and exert its osmotic effect. No additional preparation is required.

Serious adverse events are rare but may include severe rectal bleeding, allergic reactions such as rash or swelling, and electrolyte disturbances if excessive fluid loss occurs. Patients should seek immediate medical attention if they experience unexpected bleeding, signs of hypersensitivity, or prolonged diarrhea.

Milax 1,0 should be avoided in individuals with known hypersensitivity to glycerol, in cases of suspected mechanical bowel obstruction, severe dehydration, or active rectal disease such as ulcerative colitis flare. Children under two years of age should only use the product under direct medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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