Mildison Lipid (Hydrocortisone)

• Hydrocortisone is a topical corticosteroid that modulates inflammatory pathways in skin disorders.
• Eczema: reduces redness, swelling and itching associated with the condition.
• Atopic dermatitis: alleviates chronic inflammation and pruritus, improving skin barrier function.
• Contact dermatitis: diminishes acute inflammatory response caused by irritants or allergens.
• Inflammatory skin disorders: provides anti‑inflammatory relief for various dermatoses where corticosteroid therapy is indicated.

• Hydrocortisone penetrates the epidermis and binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and interacts with glucocorticoid response elements. This modulates gene transcription, leading to decreased synthesis of pro‑inflammatory cytokines, prostaglandins, and leukotrienes, while inhibiting immune cell activation and migration, thereby reducing local inflammation.

Topical hydrocortisone may cause local and, rarely, systemic adverse reactions.

Common Side Effects

• Burning or stinging sensation at the application site.
• Mild skin irritation or erythema.
• Pruritus or itching.
• Dryness or flaking of the skin.
• Folliculitis or acneiform eruptions.
• Temporary worsening of dermatitis.

Serious or Rare Side Effects

• Skin atrophy or thinning with prolonged use.
• Hypopigmentation or depigmentation of treated areas.
• Allergic contact dermatitis or severe hypersensitivity reaction.
• Systemic absorption leading to adrenal suppression, especially with extensive application.
• Secondary bacterial, fungal or viral infection of the skin.
• Development of telangiectasia or striae.

• When using Mildison Lipid, several precautions should be observed to minimize risks.
• Avoid use on infected or ulcerated skin: risk of systemic absorption and worsening infection.
• Do not apply to large surface areas for prolonged periods: may increase systemic exposure.
• Limit use in children under 2 years: heightened susceptibility to systemic effects.
• Discontinue if severe irritation, rash, or allergic reaction occurs: seek medical advice.
• Store at room temperature: keep in the original container, protect from moisture and light.

Hydrocortisone can interact with other agents applied to the skin or taken systemically.

Major Interactions (Avoid)

• Concurrent systemic corticosteroids: additive systemic glucocorticoid effects.
• Potent CYP3A4 inhibitors (e.g., ketoconazole): may increase local drug concentration.
• Immunosuppressive biologics: heightened risk of infection.

Moderate Interactions (Monitor Closely)

• NSAIDs applied to the same area: may increase local irritation.
• Skin moisturizers or occlusive dressings: can enhance absorption.
• Antifungal creams containing azoles: potential for increased local effect.