Mildison Lipid (Hydrocortisone)

• Hydrocortisone is a topical corticosteroid that modulates inflammatory pathways in skin disorders.
• Dermatitis: reduces redness, swelling and itching associated with inflammatory skin lesions.
• Eczema: alleviates flare‑ups by decreasing local immune response and moisture loss.
• Psoriasis: softens plaques and diminishes scaling through anti‑inflammatory action.
• Allergic skin reactions: calms hypersensitivity‑driven redness and pruritus.

• Hydrocortisone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and regulates gene transcription. This interaction suppresses pro‑inflammatory cytokine production, inhibits leukocyte migration, and reduces vascular permeability, resulting in decreased edema, erythema, and pruritus at the site of application.

Topical hydrocortisone may cause local skin reactions, most of which are mild and reversible.

Common Side Effects

• Burning or stinging sensation at the application site.
• Mild itching or dryness.
• Redness or mild irritation.
• Acne‑like eruptions or folliculitis.

Serious or Rare Side Effects

• Skin atrophy or thinning with prolonged use.
• Telangiectasia (visible small blood vessels).
• Hypopigmentation or depigmentation of the skin.
• Allergic contact dermatitis.
• Secondary bacterial, fungal or viral infection.
• Systemic absorption leading to adrenal suppression (rare).

• When using Mildison Lipid, consider the following safety measures.
• Assess severity: limit use to mild‑to‑moderate inflammatory skin conditions.
• Avoid occlusion: do not cover treated area with airtight dressings unless directed.
• Limit duration: apply for the shortest effective period as advised by a clinician.
• Monitor for infection: discontinue if signs of bacterial, fungal or viral infection appear.
• Pregnancy and lactation: consult a healthcare professional before initiating therapy.
• Store at room temperature: keep in the original container, protect from moisture and light.

Hydrocortisone may interact with other agents applied to the skin or absorbed systemically.

Major Interactions (Avoid)

• Concurrent systemic corticosteroids: may increase systemic glucocorticoid effects.
• Potent CYP3A4 inhibitors (e.g., ketoconazole) applied topically: may raise local steroid concentration.
• Strong topical antifungals used on the same area: risk of enhanced steroid activity.

Moderate Interactions (Monitor Closely)

• Topical NSAIDs applied to the same site: may increase local irritation.
• Antibiotic ointments: monitor for additive skin sensitivity.
• Photosensitizing agents: advise sun protection and limit UV exposure.