Mildison Lipid (Hydrocortisone)

Hydrocortisone is a topical corticosteroid that acts on inflammatory skin disorders.

• Eczema: reduces redness, itching and swelling associated with the condition.
• Dermatitis: alleviates inflammation and discomfort in various forms of dermatitis.
• Inflammatory skin conditions: provides anti‑inflammatory relief for other skin inflammations such as contact dermatitis.

• Hydrocortisone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This leads to decreased synthesis of prostaglandins, leukotrienes and cytokines, thereby reducing inflammation, suppressing immune responses, and limiting vascular permeability in the treated skin area.

Hydrocortisone may cause local and systemic adverse reactions when applied to the skin.

Common Side Effects

• Skin irritation or burning sensation at the application site.
• Pruritus (itching) or mild rash.
• Dryness or peeling of the skin.
• Folliculitis or acneiform eruptions.
• Mild erythema.
• Temporary discoloration of the skin.

Serious or Rare Side Effects

• Allergic contact dermatitis with severe swelling.
• Skin atrophy or thinning with prolonged use.
• Hypopigmentation or depigmentation of treated areas.
• Secondary bacterial, fungal or viral infection.
• Systemic absorption leading to adrenal suppression.
• Severe allergic reaction (anaphylaxis) in rare cases.

When using Hydrocortisone topical products, certain precautions should be observed.

• Assess severity: limit use to mild‑moderate conditions unless directed by a clinician.
• Duration: avoid prolonged continuous application; follow prescriber recommendations.
• Occlusion: do not cover treated area with airtight dressings unless advised.
• Infected skin: avoid use on open wounds or infected lesions.
• Pediatric use: exercise caution in children under two years of age.
• Store at room temperature: keep in original packaging, protect from moisture and light.

Hydrocortisone topical therapy can interact with other agents applied to the skin or taken systemically.

Major Interactions (Avoid)

• Systemic corticosteroids: concurrent use may increase risk of systemic glucocorticoid effects.
• Potent CYP3A4 inhibitors applied locally (e.g., ketoconazole): may raise local drug exposure.

Moderate Interactions (Monitor Closely)

• NSAIDs applied to the same area: may increase local irritation.
• Skin sensitizers such as benzoyl peroxide: may enhance irritation or allergic response.
• Antifungal creams: may alter absorption and efficacy.
• Immunosuppressive agents: may augment local immunosuppression, increasing infection risk.