Mildison Lipid (Hydrocortisone)

Hydrocortisone is used topically to manage inflammatory skin disorders.

• Eczema: reduces redness, swelling, and itching associated with atopic dermatitis.
• Contact dermatitis: alleviates inflammation caused by irritant or allergic reactions.
• Insect bites: diminishes local swelling and pruritus from bites.
• Psoriasis (mild): helps control mild plaque lesions and associated discomfort.
• Seborrheic dermatitis: softens scaling and eases irritation on scalp and face.
• Minor burns: soothes superficial thermal injury and reduces erythema.

• Hydrocortisone penetrates the epidermis and binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus. This complex interacts with glucocorticoid response elements on DNA, modulating transcription of inflammatory mediators. The result is decreased synthesis of prostaglandins, leukotrienes, and cytokines, as well as inhibition of phospholipase A2 activity, leading to reduced vasodilation, edema, and immune cell infiltration at the site of application.

Topical hydrocortisone may cause local and, rarely, systemic adverse reactions.

Common Side Effects

• Burning sensation: transient stinging at the application site.
• Itching: mild pruritus after use.
• Dryness: skin may become flaky or rough.

Serious or Rare Side Effects

• Skin atrophy: thinning of the dermis with prolonged use.
• Secondary infection: bacterial or fungal overgrowth due to local immunosuppression.
• Systemic adrenal suppression: reduced cortisol production with extensive or prolonged application.

When using Mildison Lipid, consider the following safety measures.

• Avoid use on broken or infected skin: may increase systemic absorption.
• Limit duration to 7 days: prolonged use raises risk of skin atrophy.
• Do not apply to face, groin or axillae unless directed: higher sensitivity in these areas.
• Use with caution in children: higher surface‑area‑to‑body‑mass ratio.
• Avoid occlusive dressings: can enhance drug penetration.
• Store at ambient temperature: keep in original container, protect from moisture and light.

Hydrocortisone can interact with other topical or systemic agents.

Major Interactions (Avoid)

• Systemic corticosteroids: additive glucocorticoid effect may cause systemic side effects.
• Potent CYP3A4 inhibitors applied to the same area (e.g., ketoconazole): increased hydrocortisone absorption.

Moderate Interactions (Monitor Closely)

• Topical NSAIDs: may increase local irritation.
• Antibiotic creams (e.g., mupirocin): potential reduced efficacy of either agent.
• Phototherapy: may heighten skin sensitivity and risk of burns.
• Antifungal agents: concurrent use may alter skin barrier and affect absorption.