Product image of Mildronate (Meldonium Dihydrate) supplied by GNH India

Mildronate

Active Ingredient:
Meldonium Dihydrate
Origin:
EU

Mildronate (Meldonium Dihydrate)

Meldonium Dihydrate, the active ingredient in Mildronate, is a metabolic modulator presented as a tablet for oral use. It is employed to support cardiac energy metabolism in patients with ischemic heart disease, heart failure, and peripheral vascular disorders, improving exercise tolerance and reducing angina symptoms. Clinical studies have shown benefits in myocardial efficiency and reduced fatigue during physical activity. The drug is administered under medical supervision and is part of comprehensive cardiovascular management protocols.

GNH India supplies Mildronate as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Grindeks

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Mildronate acts on metabolic pathways that influence cardiac and vascular health.
  • Ischemic heart disease: enhances myocardial energy efficiency and lessens angina attacks.
  • Heart failure: supports cardiac output by shifting myocardial substrate utilization.
  • Peripheral arterial disease: improves limb perfusion and exercise capacity.
  • Angina pectoris: reduces frequency and severity of chest pain episodes.

How It Works

  • Meldonium inhibits the biosynthesis of carnitine, decreasing fatty‑acid transport into mitochondria and promoting glucose oxidation. This metabolic shift reduces oxygen demand of cardiac cells, improves ATP production efficiency, and protects myocardial tissue during ischemic stress, thereby supporting overall cardiovascular function.

Side Effects

Mildronate may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headedness.
  • Insomnia: difficulty initiating sleep.
  • Gastrointestinal discomfort: abdominal pain or dyspepsia.
  • Skin rash: mild erythematous eruptions.

Serious or Rare Side Effects

  • Allergic reactions: hives, swelling, or anaphylaxis.
  • Cardiac arrhythmia: irregular heart rhythms.
  • Hypotension: significant drop in blood pressure.
  • Liver enzyme elevation: signs of hepatic stress.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

When considering Mildronate therapy, several safety measures are recommended.

  • Cardiac assessment: evaluate baseline heart function before initiation.
  • Renal monitoring: check kidney function periodically.
  • Hepatic caution: avoid in severe liver impairment.
  • Blood pressure monitoring: be vigilant for hypotensive episodes.
  • Pregnancy and lactation: use only if potential benefits outweigh risks.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mildronate can interact with other medications, requiring attention to potential effects.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Antihypertensive agents: may potentiate hypotensive response.

Moderate Interactions (Monitor Closely)

  • Statins: monitor for increased muscle toxicity.
  • Diuretics: watch electrolyte balance.
  • Other metabolic modulators: assess combined efficacy and safety.

Frequently Asked Questions

Mildronate is indicated for the management of ischemic heart disease, chronic heart failure, peripheral arterial disease, and angina pectoris. It helps improve cardiac energy metabolism and exercise tolerance in these cardiovascular conditions.

Meldonium Dihydrate inhibits carnitine synthesis, reducing fatty‑acid oxidation and favoring glucose oxidation in heart muscle cells. This metabolic shift lowers oxygen demand, enhances ATP production efficiency, and protects myocardial tissue during periods of reduced blood flow.

The dosage of Mildronate is determined by the prescribing healthcare professional based on the individual patient's condition, severity, and response to therapy. Patients should follow the prescriber's instructions and not adjust the dose on their own.

Mildronate should be used during pregnancy or lactation only if the potential benefits justify the possible risks to the fetus or infant. Healthcare providers must evaluate each case carefully before prescribing the medication to pregnant or nursing women.

To place an order, submit an enquiry on the Mildronate product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details, and necessary import documentation.

Mildronate uniquely targets carnitine biosynthesis, offering a distinct mechanism compared with agents that primarily act as vasodilators or beta‑blockers. Its metabolic effects can complement other cardiovascular drugs, but comparative efficacy and safety should be assessed by the treating physician.

Mildronate tablets should be stored at temperatures below 25 °C, in their original packaging, protected from moisture and direct sunlight. Maintaining these conditions helps preserve the product’s stability and potency.

Mildronate is supplied as oral tablets and is taken by mouth with water, typically under the guidance of a healthcare professional. The exact administration schedule is determined by the prescriber based on the patient’s therapeutic needs.

Serious risks include severe allergic reactions such as anaphylaxis, cardiac arrhythmias, significant hypotension, and rare but serious skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Mildronate is contraindicated in patients with known hypersensitivity to Meldonium or any tablet excipients, and should be avoided in individuals with severe hepatic impairment, uncontrolled hypotension, or those taking monoamine oxidase inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.