Product image of Milurit (Allopurinol) supplied by GNH India

Milurit

Active Ingredient:
Allopurinol
Origin:
EU

Milurit (Allopurinol)

Allopurinol, the active ingredient in Milurit, is a xanthine oxidase inhibitor presented as an oral tablet for systemic use. It reduces uric acid production and is employed in the management of gout, hyperuricemia, and the prevention of tumor lysis syndrome in adult patients.

GNH India supplies Milurit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets, offering consistent batch release, comprehensive documentation, and responsive technical support.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Allopurinol is indicated for conditions involving excess uric acid production and is used in the management of gout and related disorders.

  • Gout: lowers serum uric acid to prevent acute attacks and reduce tophi formation.
  • Hyperuricemia: maintains target uric acid levels to avoid crystal deposition.
  • Tumor lysis syndrome prophylaxis: reduces uric acid surge during chemotherapy‑induced cell breakdown.

How It Works

  • Allopurinol is a structural analogue of hypoxanthine that competitively inhibits the enzyme xanthine oxidase. By blocking this key step in purine catabolism, the conversion of hypoxanthine to xanthine and xanthine to uric acid is reduced, leading to decreased serum uric acid concentrations and diminished crystal formation. The effect is dose‑dependent and persists after the drug is cleared because its metabolite, oxypurinol, continues to inhibit the enzyme.

Side Effects

Allopurinol may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Rash: mild skin eruptions or itching.
  • Nausea: feeling of sickness often with or without vomiting.
  • Vomiting: expulsion of stomach contents.
  • Diarrhea: loose or watery stools.
  • Abdominal pain: discomfort in the stomach area.
  • Elevated liver enzymes: mild increase in hepatic transaminases.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin detachment and mucosal involvement.
  • Toxic epidermal necrolysis: life‑threatening skin loss.
  • Agranulocytosis: marked reduction in white blood cells.
  • Hepatitis: inflammation of the liver with possible jaundice.
  • Bone marrow suppression: pancytopenia or anemia.
  • Hypersensitivity syndrome: fever, rash, organ involvement.

Precautions & Warnings

When prescribing Allopurinol, clinicians should consider several safety measures to minimise risks.

  • Renal impairment: adjust dose and monitor renal function closely.
  • Gout flare: initiate therapy with anti‑inflammatory prophylaxis to avoid acute attacks.
  • Hypersensitivity: discontinue immediately if rash or systemic symptoms develop.
  • Pregnancy and lactation: use only if benefits outweigh potential risks, as data are limited.
  • Drug interactions: review concomitant medications for possible dose adjustments.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

Avoid Interactions

Allopurinol can alter the pharmacokinetics of several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Azathioprine: increased risk of bone marrow suppression.
  • Mercaptopurine: heightened toxicity and myelosuppression.
  • Theophylline: elevated plasma levels leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: enhanced anticoagulant effect, monitor INR.
  • Thiazide diuretics: may reduce uric acid‑lowering efficacy.
  • ACE inhibitors: possible increase in serum creatinine, monitor renal function.

Frequently Asked Questions

Milurit contains allopurinol and is used to lower elevated uric acid levels. It is prescribed for the treatment and long‑term management of gout, for chronic hyperuricemia, and as a prophylactic agent to prevent tumor lysis syndrome in patients undergoing intensive chemotherapy.

Allopurinol is a structural analogue of hypoxanthine that competitively inhibits the enzyme xanthine oxidase. This blockade reduces the conversion of purine metabolites to uric acid, thereby decreasing serum uric acid concentrations and limiting crystal formation in joints and tissues.

The dose of Milurit is individualized by the prescribing clinician based on the patient’s renal function, severity of hyperuricemia, and therapeutic goals. The prescriber determines the appropriate strength, frequency, and duration of treatment.

Safety data for allopurinol in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To order Milurit, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to allopurinol is febuxostat, another xanthine oxidase inhibitor. Both lower uric acid, but febuxostat may be preferred in patients with moderate renal impairment because it is less dependent on renal excretion. Choice of therapy depends on individual patient factors, tolerability and clinician judgment.

Milurit should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or direct sunlight.

Milurit is administered orally, usually as a tablet taken with or without food. The exact dosing schedule, including whether it is taken once daily or divided doses, is determined by the prescribing physician based on the patient’s clinical condition.

Serious risks include severe cutaneous adverse reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, as well as hypersensitivity syndrome, agranulocytosis, and hepatitis. Patients should seek immediate medical attention if they develop rash, fever, jaundice, or unexplained bleeding.

Milurit is contraindicated in patients with known hypersensitivity to allopurinol or any of its excipients. Caution is advised in individuals with severe renal impairment, active gout flares, or those taking drugs that have major interactions, such as azathioprine or mercaptopurine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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