Product image of Milurit (Allopurinol) supplied by GNH India

Milurit

Active Ingredient:
Allopurinol
Origin:
EU

Milurit (Allopurinol)

Allopurinol, the active ingredient in Milurit, is a xanthine oxidase inhibitor presented as an oral tablet for oral use. It lowers uric acid production and is employed in the management of gout, hyperuricemia, and uric‑acid kidney stones in adult patients. It is typically prescribed by physicians after laboratory confirmation of elevated serum urate levels.

GNH India supplies Milurit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures reliable delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Allopurinol, the active component of Milurit, targets uric acid metabolism and is indicated for several gout‑related conditions.

  • Gout: reduces serum uric acid levels to prevent acute flares and tophi formation in patients with chronic gout.
  • Hyperuricemia: maintains target uric acid concentrations, lowering the risk of disease progression in individuals with persistently elevated serum urate.
  • Uric acid kidney stones: decreases urinary uric acid saturation, helping to prevent formation and recurrence of uric‑acid calculi.
  • Asymptomatic hyperuricemia: may be used to control urate levels in patients at risk of developing gout or renal complications.

How It Works

  • Allopurinol is a structural analogue of hypoxanthine that competitively inhibits the enzyme xanthine oxidase. By blocking this key step in purine catabolism, the conversion of hypoxanthine to xanthine and of xanthine to uric acid is reduced, leading to decreased production of uric acid and lower serum urate concentrations. The metabolite oxypurinol contributes to prolonged enzyme inhibition. The inhibition is dose‑dependent and persists until new enzyme is synthesized.

Side Effects

Allopurinol may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Rash: mild skin eruptions or itching.
  • Nausea: feeling of sickness, sometimes with vomiting.
  • Diarrhea: loose stools that may be watery.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: severe skin reactions requiring immediate medical attention.
  • Agranulocytosis: marked reduction in white blood cells, increasing infection risk.
  • Hepatitis: inflammation of the liver that can progress to failure.

Precautions & Warnings

When prescribing Milurit, clinicians should consider several precautionary measures to minimise risk and optimise therapy.

  • Renal impairment: adjust dose and monitor renal function regularly.
  • Hepatic disease: use with caution and observe liver function tests.
  • History of hypersensitivity: avoid use in patients with known allergy to allopurinol.
  • Concomitant azathioprine or mercaptopurine: monitor blood counts for myelosuppression.
  • Pregnancy and lactation: prescribe only if potential benefit outweighs potential risk.
  • Store at ambient temperature: keep tablets in original container, protect from moisture and heat.

Avoid Interactions

Allopurinol can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Azathioprine: increased risk of bone marrow suppression.
  • Mercaptopurine: heightened toxicity due to reduced metabolism.
  • Warfarin: possible increase in INR and bleeding risk.
  • Theophylline: elevated plasma concentrations leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics (e.g., thiazides): may precipitate allopurinol hypersensitivity; monitor for rash.
  • ACE inhibitors: watch renal function and serum uric acid levels.
  • NSAIDs: may affect uric acid excretion; monitor urate concentrations.

Frequently Asked Questions

Milurit contains allopurinol, which is prescribed to lower elevated uric acid levels. It is used in the treatment of gout, to prevent acute attacks and tophi, in chronic hyperuricemia, and to reduce the risk of uric‑acid kidney stone formation.

Allopurinol is a structural analogue of hypoxanthine that competitively inhibits xanthine oxidase, the enzyme responsible for converting hypoxanthine to xanthine and xanthine to uric acid. By blocking this pathway, uric acid production falls, leading to lower serum urate concentrations.

The dose of Milurit is individualized. A qualified prescriber determines the appropriate amount based on the patient’s serum urate level, renal function, and overall clinical condition. No fixed regimen is provided here.

Safety data for allopurinol in pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under medical supervision.

To order Milurit, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to allopurinol is febuxostat, another xanthine oxidase inhibitor. Both lower uric acid, but febuxostat may be preferred in patients with moderate renal impairment, while allopurinol is often less expensive and has a longer safety record. Choice depends on individual patient factors and physician judgment.

Milurit tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and heat. Keep the product out of reach of children and avoid exposure to direct sunlight.

Milurit is taken orally, usually with a full glass of water. It can be taken with or without food, but consistency with meals may help reduce gastrointestinal upset. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious adverse reactions include severe skin disorders such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, agranulocytosis (dangerously low white‑blood‑cell count), and hepatitis or other significant liver injury. Any signs of rash, fever, sore throat, jaundice, or unusual fatigue should prompt immediate medical evaluation.

Milurit is contraindicated in patients with a known hypersensitivity to allopurinol or any component of the formulation. It should also be avoided in individuals with severe renal impairment unless dose adjustments are made, and in patients taking certain chemotherapeutic agents without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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