Product image of Milurit (Allopurinol) supplied by GNH India

Milurit

Active Ingredient:
Allopurinol
Origin:
EU

Milurit (Allopurinol)

Allopurinol, the active ingredient in Milurit, is a xanthine oxidase inhibitor presented as a unknown/unknown for oral use. It treats gout, hyperuricemia and is used to prevent tumor lysis syndrome in patients at risk.

GNH India supplies Milurit as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Proterapia

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Indications & Clinical Uses

  • Milurit, a xanthine oxidase inhibitor, is employed in conditions related to excess uric acid production.
  • Gout: reduces serum uric acid to prevent acute attacks and chronic joint damage.
  • Hyperuricemia: maintains lower uric acid levels to avoid crystal deposition and renal complications.
  • Prevention of tumor lysis syndrome: lowers uric acid generated during rapid cell turnover in chemotherapy patients.

How It Works

  • Allopurinol is a structural analogue of hypoxanthine that competitively inhibits the enzyme xanthine oxidase. By blocking this enzyme, it prevents the oxidation of hypoxanthine to xanthine and xanthine to uric acid, thereby decreasing the production of uric acid and lowering its concentration in the blood.

Side Effects

Adverse reactions may occur with Milurit and are categorized by frequency.

Common Side Effects

  • Rash or mild skin irritation
  • Nausea or vomiting
  • Diarrhea or abdominal discomfort
  • Elevated liver enzymes
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Severe hypersensitivity reactions
  • Agranulocytosis or bone‑marrow suppression
  • Hepatic failure or severe liver injury
  • Acute renal impairment
  • Severe cutaneous adverse reactions

Precautions & Warnings

  • Milurit requires careful consideration of patient-specific factors before use.
  • Renal function: adjust dose in patients with impaired renal clearance.
  • Hepatic function: monitor liver enzymes in patients with liver disease.
  • Allergy: avoid if known hypersensitivity to allopurinol or excipients.
  • Pregnancy: use only if benefits outweigh potential risks.
  • Drug interactions: review concomitant medications such as azathioprine.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Milurit can interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Azathioprine: may increase risk of bone‑marrow suppression.
  • Mercaptopurine: heightened toxicity risk.
  • Warfarin: possible enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may reduce uric‑acid‑lowering efficacy.
  • ACE inhibitors: may increase hypersensitivity potential.
  • NSAIDs: may raise risk of renal impairment.

Frequently Asked Questions

Milurit contains allopurinol and is indicated for the management of gout, chronic hyperuricemia, and the prevention of tumor lysis syndrome in patients receiving chemotherapy. By lowering serum uric acid, it helps reduce the risk of acute gout attacks and uric‑acid‑related kidney complications.

Allopurinol is a hypoxanthine analogue that competitively inhibits xanthine oxidase, the enzyme responsible for converting hypoxanthine to xanthine and xanthine to uric acid. This inhibition decreases uric acid production, leading to lower blood uric‑acid concentrations.

The dosage of Milurit is individualized by the prescribing clinician based on the patient’s uric‑acid level, renal function, and therapeutic goal. Typical adult regimens start with a low dose and are titrated upward, but the exact amount and schedule must be determined by a qualified health professional.

Safety data for allopurinol in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician in consultation with the patient.

To place an order, submit an enquiry on the Milurit product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Milurit (allopurinol) is a first‑line xanthine oxidase inhibitor, whereas alternatives such as febuxostat belong to the same class but have different metabolic pathways and dosing considerations. Allopurinol is generally less expensive and has a long safety record, but individual response and tolerability guide the choice of therapy.

Milurit should be stored at temperatures below 25 °C, in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use it after the expiry date printed on the packaging.

Milurit is taken orally, usually with a full glass of water. It can be taken with or without food, but consistent timing each day helps maintain stable blood levels. Patients should follow the prescribing clinician’s instructions regarding dose timing and any necessary dose adjustments.

The most serious adverse reactions include severe hypersensitivity syndromes such as Stevens‑Johnson syndrome, toxic epidermal necrolysis, and drug‑induced agranulocytosis or hepatic failure. Prompt medical attention is required if signs of rash, fever, jaundice, or unexplained fatigue develop while taking Milurit.

Milurit is contraindicated in patients with a known hypersensitivity to allopurinol or any component of the formulation. Caution is also advised for individuals with severe renal impairment, active liver disease, or those taking interacting medications such as azathioprine, unless a clinician determines the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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