Product image of Milurit (Allopurinol) supplied by GNH India

Milurit

Active Ingredient:
Allopurinol
Origin:
EU

Milurit (Allopurinol)

Allopurinol, the active ingredient in Milurit, is a xanthine oxidase inhibitor presented as an oral tablet for oral use. It reduces uric acid production and is employed in the management of gout, chronic hyperuricemia, and to prevent tumor lysis syndrome in patients undergoing chemotherapy.

GNH India supplies Milurit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU‑derived quality standards and providing reliable global distribution. Our supply chain ensures product integrity from manufacture to end‑user.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Allopurinol is used in conditions where excess uric acid contributes to disease pathology.

  • Gout: lowers serum uric acid to reduce acute attacks and prevent chronic joint damage.
  • Hyperuricemia: maintains target uric acid levels to avoid crystal deposition and related complications.
  • Tumor lysis syndrome: prophylactically reduces uric acid surge during rapid cancer cell breakdown.

How It Works

  • Allopurinol is a structural analogue of hypoxanthine that competitively inhibits the enzyme xanthine oxidase. By blocking this key step in purine catabolism, the conversion of hypoxanthine to xanthine and xanthine to uric acid is reduced, leading to decreased production of uric acid and lower serum concentrations. The metabolite oxypurinol retains inhibitory activity, providing prolonged enzyme suppression after the parent drug is cleared.

Side Effects

Allopurinol may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Rash: mild skin eruption that may appear shortly after therapy initiation.
  • Gastrointestinal discomfort: nausea, vomiting or abdominal pain.
  • Elevated liver enzymes: transient increase in hepatic transaminases.
  • Pruritus: itching without visible rash.
  • Diarrhea: loose stools.
  • Dizziness: light‑headed sensation.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe mucocutaneous reaction requiring immediate medical attention.
  • Toxic epidermal necrolysis: life‑threatening skin detachment.
  • Severe hypersensitivity syndrome: fever, eosinophilia, hepatitis, and renal impairment.

Precautions & Warnings

When prescribing Allopurinol, clinicians should consider several precautionary measures to minimise risk.

  • Renal function: dose may need adjustment in patients with impaired kidney function.
  • Hepatic impairment: monitor liver enzymes, especially during initiation.
  • Hypersensitivity history: avoid in individuals with prior severe reactions to allopurinol.
  • Concomitant azathioprine or 6‑mercaptopurine: increase risk of bone marrow suppression; monitor blood counts.
  • Cardiovascular disease: use cautiously in patients with ischemic heart disease due to rare reports of arrhythmias.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Allopurinol can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Azathioprine or 6‑mercaptopurine: increased myelosuppression; avoid co‑administration.
  • Warfarin: potentiates anticoagulant effect; monitor INR closely.
  • Zidovudine: may enhance toxicity; consider alternative antiretroviral.

Moderate Interactions (Monitor Closely)

  • Theophylline: reduced clearance leading to higher plasma levels; adjust dose if needed.
  • Amoxicillin/clavulanate: may increase risk of rash; observe for skin reactions.
  • Diuretics (e.g., thiazides): can raise serum uric acid; monitor uric acid levels.

Frequently Asked Questions

Milurit contains allopurinol and is prescribed to lower elevated uric acid levels. It is used to treat acute gout attacks, manage chronic hyperuricemia, and to prevent the rapid rise in uric acid that can occur during tumor lysis syndrome in patients receiving chemotherapy.

Allopurinol is a structural analogue of hypoxanthine that competitively inhibits xanthine oxidase, the enzyme responsible for converting hypoxanthine to xanthine and xanthine to uric acid. By blocking this pathway, it reduces the production of uric acid, helping to maintain lower serum urate concentrations.

The appropriate dose of Milurit is determined by the prescribing clinician based on the patient’s specific condition, renal function, and response to therapy. Dosage may be titrated to achieve target uric acid levels while monitoring for safety and tolerability.

Safety data for allopurinol in pregnancy and lactation are limited, and the product’s pregnancy category is not definitively established. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and only under medical supervision.

To order Milurit, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to allopurinol is febuxostat, another xanthine oxidase inhibitor. Both lower uric acid, but febuxostat may be preferred in patients with mild to moderate renal impairment, whereas allopurinol is often first‑line due to longer clinical experience and lower cost. Individual safety profiles and drug‑interaction potentials differ, so choice should be individualized.

Milurit should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Milurit is taken orally, usually with a full glass of water. Tablets are swallowed whole and can be taken with or without food, unless the prescriber advises otherwise. Consistent timing each day helps maintain stable drug levels.

Serious adverse reactions include severe skin conditions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and hypersensitivity syndrome that may present with fever, rash, hepatitis, eosinophilia, or renal impairment. Immediate medical attention is required if any of these symptoms develop.

Milurit should be avoided in patients with a known hypersensitivity to allopurinol or any component of the formulation. Caution is also advised for individuals with severe renal impairment, active liver disease, or a history of severe cutaneous adverse reactions to related drugs.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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