Product image of Minims Natriumfluorescein Bausch + Lomb Ireland Limited (Fluorescein Sodium) supplied by GNH India

Minims Natriumfluorescein Bausch + Lomb Ireland Limited

Active Ingredient:
Fluorescein Sodium
Origin:
EU

Minims Natriumfluorescein Bausch + Lomb Ireland Limited (Fluorescein Sodium)

Fluorescein Sodium, the active ingredient in Minims Natriumfluorescein Bausch + Lomb Ireland Limited, is a diagnostic agent presented as a solution for ocular use. It stains damaged corneal epithelium and fluoresces under cobalt‑blue light, allowing clinicians to visualise surface defects in the eye.

GNH India supplies Minims Natriumfluorescein Bausch + Lomb Ireland Limited as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bausch + Lomb Ireland Limited

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Indications & Clinical Uses

Fluorescein Sodium is used in ophthalmology to highlight epithelial defects and assess ocular surface health.

  • Corneal abrasion: stains the lesion to delineate size and depth for proper management.
  • Ocular surface injury: enables rapid visualization of epithelial loss after trauma or chemical exposure.
  • Contact lens fitting: assists in detecting lens‑related epithelial changes during fitting procedures.

How It Works

  • Fluorescein sodium binds to exposed proteinaceous components of damaged corneal epithelium. When illuminated with cobalt‑blue light (approximately 465 nm), the bound dye emits a bright green fluorescence, providing a high‑contrast image of epithelial defects and allowing clinicians to map the extent of ocular surface injury.

Side Effects

Fluorescein sodium is generally well tolerated, but ocular irritation can occur.

Common Side Effects

  • Mild eye irritation: transient burning or stinging sensation after instillation.
  • Temporary redness: mild conjunctival hyperemia that resolves quickly.
  • Increased tearing: reflex lacrimation that clears the dye.
  • Foreign‑body sensation: feeling of grit that subsides within minutes.
  • Mild allergic reaction: localized itching or mild eyelid swelling.

Serious or Rare Side Effects

  • Severe allergic reaction: anaphylaxis or angioedema requiring immediate medical attention.
  • Corneal toxicity: prolonged exposure or high concentrations may impair epithelial healing.
  • Elevated intra‑ocular pressure: rare but reported in susceptible individuals.
  • Persistent staining: difficulty clearing the dye, potentially obscuring further examination.
  • Vision changes: temporary blurred vision due to dye film on the cornea.

Precautions & Warnings

Fluorescein sodium should be used with awareness of specific safety considerations.

  • Allergy assessment: avoid use in patients with known hypersensitivity to fluorescein or its excipients.
  • Corneal ulcer caution: limit application on active ulcers to prevent further epithelial damage.
  • Contact lens use: remove lenses before instillation and wait before reinserting to avoid staining.
  • Light source requirement: ensure appropriate cobalt‑blue illumination for accurate visualization.
  • Solution integrity: discard if the preparation appears discolored or contaminated.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Fluorescein sodium may interact with other ocular agents, requiring careful management.

Major Interactions (Avoid)

  • Topical anesthetics: concurrent use can increase corneal toxicity.
  • Other ocular dyes: simultaneous staining may cause confusing color overlap.
  • Phototoxic drugs: systemic photosensitizers may amplify ocular light reactions.

Moderate Interactions (Monitor Closely)

  • Contact lens solutions: certain preservatives can alter dye appearance.
  • Anti‑inflammatory eye drops: may affect staining intensity and interpretation.
  • Systemic sulfonamides: rare reports of cross‑reactivity; monitor for allergic signs.

Frequently Asked Questions

Minims Natriumfluorescein contains fluorescein sodium, an ophthalmic diagnostic dye used to highlight corneal abrasions, epithelial defects and other ocular surface injuries. When applied to the eye and examined under cobalt‑blue light, the dye fluoresces, allowing clinicians to see the size, shape and location of the damage for accurate assessment and treatment planning.

Fluorescein sodium binds to exposed proteins on damaged corneal epithelium. Under cobalt‑blue illumination (around 465 nm), the bound dye emits a bright green fluorescence. This contrast makes epithelial defects visible, enabling precise mapping of abrasions, ulcer margins, or areas of epithelial loss during eye examinations.

The dose of Minims Natriumfluorescein is determined by the prescribing eye‑care professional. Typically, a single drop is instilled onto the ocular surface, and the amount may be repeated if needed for adequate staining. Exact dosing frequency and volume should follow the clinician’s instructions and the product label.

Safety data for fluorescein sodium in pregnancy and lactation are limited. It is generally classified as a Category C agent, meaning it should only be used if the potential benefit justifies any potential risk to the fetus or infant. Clinicians should evaluate each case individually and discuss possible risks with the patient.

To place an order, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifying trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Fluorescein sodium is the most widely used ocular dye for corneal staining because of its strong fluorescence, rapid onset, and short duration of action. Alternatives such as lissamine green or rose bengal are used for different staining patterns or when fluorescein intolerance occurs. Fluorescein provides clearer visualization of epithelial defects, while the others may highlight cell death or mucous membranes.

Store Minims Natriumfluorescein at room temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from direct sunlight and moisture, and ensure the cap is tightly closed to prevent contamination. Do not freeze the solution; if the product appears discolored, discard it.

The product is administered topically to the eye. After washing hands, a single drop is placed onto the conjunctival sac of the affected eye. The clinician then examines the eye using a cobalt‑blue light source to visualize the fluorescence. Any excess dye is gently rinsed if necessary.

Serious risks, although rare, include severe allergic reactions such as anaphylaxis or angioedema, corneal toxicity with prolonged exposure, and a possible increase in intra‑ocular pressure. Patients should be monitored for signs of systemic allergy, persistent irritation, or visual changes, and immediate medical attention should be sought if these occur.

Minims Natriumfluorescein should not be used in individuals with a known hypersensitivity to fluorescein sodium or any of the formulation’s excipients. It is also contraindicated in eyes with active severe infections or uncontrolled inflammation where dye application could exacerbate the condition. Clinicians must assess each patient’s medical history before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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