Product image of Minprostin (Dinoprostone) supplied by GNH India

Minprostin

Active Ingredient:
Dinoprostone
Origin:
EU

Minprostin (Dinoprostone)

Dinoprostone, the active ingredient in Minprostin, is a prostaglandin E2 analog presented as a vaginal formulation for vaginal use. It is employed to promote cervical ripening and to induce uterine contractions in obstetric settings.
GNH India supplies Minprostin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Pfizer Aps

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Minprostin belongs to the prostaglandin class and is used in obstetric care to facilitate labor and manage early pregnancy loss.

  • Cervical ripening: softens and dilates the cervix to prepare for labor.
  • Induction of labor: stimulates uterine contractions to initiate delivery in term or post‑term pregnancies.
  • Management of incomplete abortion: promotes expulsion of retained products of conception.
  • Post‑term pregnancy induction: assists in initiating labor when pregnancy extends beyond 42 weeks.

How It Works

  • Dinoprostone binds to prostaglandin E2 (EP) receptors on uterine smooth muscle and cervical tissue, increasing intracellular cyclic AMP levels. This biochemical cascade leads to cervical softening, effacement, and dilation, while simultaneously enhancing myometrial contractility to promote uterine contractions essential for labor induction.

Side Effects

Minprostin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Vaginal bleeding or spotting.
  • Nausea or vomiting.
  • Abdominal cramping or pain.
  • Fever or chills.
  • Diarrhea.

Serious or Rare Side Effects

  • Uterine rupture.
  • Severe hemorrhage.
  • Fetal distress or abnormal heart rate patterns.
  • Allergic reactions such as rash, itching, or anaphylaxis.
  • Pulmonary edema.

Precautions & Warnings

Before using Minprostin, clinicians should consider several safety measures.

  • Assess cervical status: confirm that the cervix is appropriate for prostaglandin use.
  • Monitor fetal heart rate: continuous monitoring is recommended during administration.
  • Avoid in patients with prior uterine surgery: scarred uterus increases rupture risk.
  • Use with caution in multiple gestations: heightened risk of hyperstimulation.
  • Do not exceed recommended exposure time: follow prescriber instructions closely.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Dinoprostone can interact with other agents that affect uterine activity or prostaglandin pathways.

Major Interactions (Avoid)

  • Concomitant oxytocin: may cause excessive uterine hyperstimulation.
  • Other prostaglandin analogs: additive effects increase risk of uterine rupture.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may mask fever, reducing early detection of infection.
  • Magnesium sulfate: can potentiate uterine relaxation, diminishing efficacy.
  • Beta‑agonists: may alter uterine contractility and affect labor progression.

Frequently Asked Questions

Minprostin is a vaginal prostaglandin E2 analog used in obstetrics to ripen the cervix, induce labor in term or post‑term pregnancies, and assist in the medical management of incomplete abortions.

Dinoprostone binds to EP receptors on uterine smooth muscle and cervical tissue, raising intracellular cAMP. This promotes cervical softening, effacement, and dilation while stimulating coordinated uterine contractions needed for labor.

The dosage and regimen of Minprostin are determined by the prescribing clinician based on the patient’s obstetric condition, cervical status, and gestational age. Specific dosing instructions are not provided here.

Minprostin is intended for use during pregnancy to induce labor or manage early pregnancy loss. Its safety profile in breastfeeding has not been established, and clinicians should weigh benefits against potential risks.

To order Minprostin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative is misoprostol, another prostaglandin used for cervical ripening and labor induction. Dinoprostone (Minprostin) has a shorter half‑life and is often preferred when a more controlled, titratable effect is needed, whereas misoprostol is less expensive but may cause more gastrointestinal side effects.

Minprostin should be stored at room temperature, below 25 °C, in its original packaging. Protect it from moisture and direct light to maintain stability. Do not refrigerate unless specifically instructed by the manufacturer.

Minprostin is administered vaginally, typically as tablets or a gel inserted into the posterior fornix of the vagina. The exact method and number of doses are determined by the treating physician and monitored with cervical and fetal assessments.

Serious risks include uterine rupture, severe maternal hemorrhage, fetal distress, and rare allergic reactions such as anaphylaxis. Continuous fetal monitoring and careful observation for signs of hyperstimulation are essential during treatment.

Minprostin is contraindicated in patients with a known hypersensitivity to dinoprostone or other prostaglandins, previous uterine surgery (e.g., classical cesarean section), active fetal distress, severe maternal cardiac disease, or unexplained vaginal bleeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Dinoprostone

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT