Product image of Miorelique (Baclofen) supplied by GNH India

Miorelique

Active Ingredient:
Baclofen
Origin:
EU

Miorelique (Baclofen)

Baclofen, the active ingredient in Miorelique, is a muscle relaxant presented as an oral formulation for oral use. It is employed to reduce muscle spasticity in conditions such as multiple sclerosis and spinal cord injury, acting on the central nervous system to improve mobility and comfort.

GNH India supplies Miorelique as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU regulatory standards and is provided for prescription use. It is manufactured under strict quality controls to ensure consistency and safety.

Manufacturer / TM Owner

Provident Pharmaceuticals Ltd

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Indications & Clinical Uses

  • Baclofen is used to manage spasticity associated with central nervous system disorders.
  • Spasticity associated with multiple sclerosis: reduces muscle tone and improves motor function.
  • Spasticity due to spinal cord injury: alleviates hypertonia and facilitates rehabilitation.
  • Other central nervous system disorders causing muscle hypertonia: decreases involuntary muscle contractions.

How It Works

  • Baclofen acts as an agonist at GABA_B receptors in the spinal cord and brainstem. By stimulating these metabotropic receptors, it inhibits the release of excitatory neurotransmitters such as glutamate and aspartate, leading to decreased neuronal firing and reduced transmission of reflex arcs that cause muscle hypertonia. This central inhibition results in relaxation of skeletal muscles and attenuation of spasticity through modulation of calcium channels.

Side Effects

Baclofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Drowsiness: feeling of sleepiness or reduced alertness.
  • Dizziness: light‑headed sensation or balance disturbance.
  • Weakness: reduced muscle strength or fatigue.
  • Nausea: upset stomach or urge to vomit.

Serious or Rare Side Effects

  • Seizures: occurrence of convulsive episodes.
  • Respiratory depression: slowed or shallow breathing.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing Baclofen, clinicians should consider several safety precautions to minimize risk.

  • Assess renal function: adjust dose in patients with impaired clearance.
  • Monitor for hypotension: watch blood pressure especially after dose initiation.
  • Evaluate CNS depression: avoid concurrent sedatives that may enhance drowsiness.
  • Counsel on abrupt discontinuation: taper gradually to prevent withdrawal symptoms.
  • Pregnancy and lactation: use only if benefit outweighs potential risk (category unknown).
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Baclofen can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Opioids: combined CNS depression may cause severe respiratory depression.
  • Antihypertensives: additive hypotensive effect can lead to marked blood pressure drop.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: may increase sedation and dizziness.
  • Anticonvulsants: may enhance central nervous system depression.
  • Alcohol: can potentiate drowsiness and impair coordination.

Frequently Asked Questions

Miorelique contains baclofen, which is prescribed to treat muscle spasticity. It is indicated for patients with spasticity related to multiple sclerosis, spinal cord injury, or other central nervous system disorders that cause increased muscle tone and involuntary contractions.

Baclofen works by activating GABA_B receptors in the spinal cord and brainstem. This activation reduces the release of excitatory neurotransmitters, dampening nerve signals that cause muscle over‑activity, thereby helping to relax stiff or spastic muscles.

The dosage of baclofen is individualized. A qualified prescriber determines the appropriate starting dose, titration schedule, and maintenance dose based on the patient’s condition, response, and renal function. No fixed regimen is provided here.

Safety data for baclofen during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by the treating physician.

To order Miorelique, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

The most common alternative to baclofen is tizanidine, another centrally acting muscle relaxant. Baclofen primarily targets GABA_B receptors, while tizanidine acts on α2‑adrenergic receptors. Differences in side‑effect profiles, dosing frequency, and renal clearance may influence a clinician’s choice between them.

Miorelique should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Miorelique is taken orally. The tablet (or other oral form) should be swallowed whole with a glass of water, unless the prescribing information advises otherwise. It is usually taken with or without food as directed by the prescriber.

Serious risks associated with baclofen include seizures, respiratory depression, and severe allergic reactions such as anaphylaxis. Patients should be instructed to seek immediate medical attention if they experience difficulty breathing, convulsions, or signs of a severe allergic response.

Miorelique is contraindicated in patients with known hypersensitivity to baclofen or any of its excipients. Caution is also advised for individuals with severe renal impairment, uncontrolled epilepsy, or those who are pregnant or breastfeeding without a clear medical justification.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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