Product image of Miorexil (Thiocolchicoside) supplied by GNH India

Miorexil

Active Ingredient:
Thiocolchicoside
Origin:
EU

Miorexil (Thiocolchicoside)

Thiocolchicoside, the active ingredient in Miorexil, is a skeletal muscle relaxant presented as an injectable solution for intramuscular use. It acts on the central nervous system to alleviate muscle spasm, musculoskeletal pain, and acute low back pain, primarily in adult patients requiring short‑term relief.

GNH India supplies Miorexil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Spa – Società Prodotti Antibiotici S.P.A.

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Indications & Clinical Uses

Thiocolchicoside is indicated for conditions involving skeletal muscle spasm and related pain.

  • Muscle spasm: reduces involuntary muscle contraction and associated discomfort.
  • Musculoskeletal pain: alleviates pain linked to muscle strain or injury.
  • Acute low back pain: provides short‑term relief of pain and functional limitation.

How It Works

  • Thiocolchicoside antagonizes glycine receptors in the spinal cord, diminishing inhibitory neurotransmission and producing central muscle relaxation. By blocking glycine‑mediated pathways, it reduces the excitability of motor neurons, leading to decreased muscle tone and relief of spasm without significant peripheral effects.

Side Effects

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Drowsiness: increased sleepiness or reduced alertness.
  • Nausea: feeling of queasiness or urge to vomit.
  • Headache: mild to moderate cranial pain.
  • Injection site pain: discomfort at the intramuscular injection site.
  • Hypotension: transient lowering of blood pressure.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.
  • Liver enzyme elevation: abnormal hepatic function tests.
  • Seizures: rare occurrence of convulsive episodes.
  • Severe hypotension: marked drop in blood pressure requiring medical attention.

Precautions & Warnings

Precautions should be observed when prescribing Thiocolchicoside.

  • Assess renal and hepatic function: adjust use if impairment is present.
  • Use with caution in the elderly: increased susceptibility to sedation and falls.
  • Avoid in patients with known hypersensitivity: discontinue if allergic signs appear.
  • Monitor for sedation: avoid operating machinery or driving if drowsy.
  • Avoid concomitant CNS depressants: may enhance sedation and respiratory depression.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Thiocolchicoside may interact with other medications.

Major Interactions (Avoid)

  • Other central muscle relaxants (e.g., baclofen, tizanidine): increased risk of profound CNS depression.
  • Monoamine oxidase inhibitors (MAOIs): potential for severe hypotension.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines or opioids: may enhance sedation and respiratory effects.
  • Antihistamines: could increase drowsiness.
  • Alcohol: may potentiate central nervous system depression.

Frequently Asked Questions

Miorexil contains the muscle relaxant thiocolchicoside and is used to treat muscle spasm, musculoskeletal pain, and acute low back pain. It provides short‑term relief by reducing involuntary muscle contractions and associated discomfort in adult patients.

Thiocolchicoside works by antagonizing glycine receptors in the spinal cord, which decreases inhibitory neurotransmission. This action reduces the excitability of motor neurons, leading to central muscle relaxation and relief of spasm without significant peripheral effects.

The dosage of Miorexil is determined by the prescribing healthcare professional based on the patient’s condition, severity of symptoms, and clinical response. The prescriber will set the appropriate dose and administration schedule.

The safety of thiocolchicoside in pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order Miorexil, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and import paperwork.

Miorexil (thiocolchicoside) differs from many other muscle relaxants by acting as a glycine‑receptor antagonist, providing central muscle relaxation without strong anticholinergic effects. Compared with agents like baclofen or tizanidine, it may have a distinct side‑effect profile and is often chosen when a different mechanism of action is desired.

Miorexil should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct light. Do not freeze the solution, and keep it out of reach of children.

Miorexil is supplied as an injectable solution for intramuscular injection. The healthcare professional administers the dose into a muscle, typically the gluteal or deltoid region, following aseptic technique and according to the prescribed regimen.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, significant liver enzyme elevations, seizures, and marked hypotension. Patients should be monitored for any signs of these reactions, and treatment should be discontinued immediately if they occur.

Miorexil should not be used by individuals with known hypersensitivity to thiocolchicoside or any excipients in the formulation. Caution is advised in patients with severe hepatic or renal impairment, and it is generally avoided in pregnant or breastfeeding women unless clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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