Product image of Miphtel (Acetylcholine Chloride) supplied by GNH India

Miphtel

Active Ingredient:
Acetylcholine Chloride
Origin:
EU

Miphtel (Acetylcholine Chloride)

Acetylcholine chloride, the active ingredient in Miphtel, is a cholinergic agonist presented as a sterile ophthalmic solution for intraocular use. It is employed to lower intraocular pressure in glaucoma and to induce pupil constriction for diagnostic and surgical eye procedures.
GNH India supplies Miphtel as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Farmigea Spa

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Indications & Clinical Uses

  • Miphtel is a cholinergic agonist used in ophthalmology to manage conditions that benefit from pupil constriction and improved aqueous outflow.
  • Glaucoma: reduces intraocular pressure by facilitating aqueous humor drainage.
  • Diagnostic procedures requiring miosis: produces pupil constriction to enhance visualization of ocular structures.
  • Surgical procedures requiring miosis: induces controlled pupil constriction to protect intraocular tissues during surgery.

How It Works

  • Acetylcholine chloride acts as a direct muscarinic receptor agonist in the eye, stimulating the sphincter pupillae and ciliary muscle. This contraction produces miosis and increases trabecular meshwork outflow of aqueous humor, thereby lowering intraocular pressure and facilitating ocular procedures.

Side Effects

Miphtel may cause ocular and systemic reactions following intraocular administration.

Common Side Effects

  • Blurred vision: temporary loss of visual clarity.
  • Eye pain or discomfort: mild irritation after dosing.
  • Headache: mild to moderate headache.
  • Brow ache: tenderness around the eyebrow region.
  • Photophobia: increased sensitivity to light.
  • Excessive tearing: increased lacrimation.

Serious or Rare Side Effects

  • Acute angle‑closure glaucoma: sudden rise in intraocular pressure.
  • Severe ocular inflammation: uveitis or iritis.
  • Corneal edema: swelling of the cornea affecting vision.
  • Systemic cholinergic toxicity: bradycardia, hypotension, or bronchospasm.
  • Allergic reaction: rash, itching, or swelling of the eyelids.

Precautions & Warnings

Before prescribing Miphtel, clinicians should evaluate patient history and ocular status.

  • Assess intraocular pressure: confirm baseline pressure and angle status.
  • Monitor systemic cholinergic effects: watch for bradycardia or hypotension.
  • Avoid in hypersensitivity: discontinue if allergic reaction occurs.
  • Caution in asthma or COPD: cholinergic stimulation may exacerbate bronchospasm.
  • Do not use in narrow‑angle glaucoma: risk of precipitating acute closure.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Miphtel can interact with other ocular or systemic agents that affect cholinergic pathways.

Major Interactions (Avoid)

  • Anticholinergic eye drops (e.g., atropine): antagonize miotic effect.
  • Systemic anticholinergics: reduce therapeutic response.
  • Cholinesterase inhibitors: may potentiate cholinergic activity.
  • Other miotic agents (e.g., pilocarpine): risk of excessive miosis.

Moderate Interactions (Monitor Closely)

  • Topical ocular anesthetics: may increase corneal toxicity.
  • Systemic beta‑blockers: additive intraocular pressure lowering.
  • Systemic antihistamines: may affect pupil response.
  • Systemic cholinergic agents: monitor for systemic toxicity.

Frequently Asked Questions

Miphtel contains acetylcholine chloride and is prescribed as an intraocular cholinergic agonist to lower intraocular pressure in glaucoma and to produce pupil constriction (miosis) for diagnostic imaging or during eye surgery.

Acetylcholine chloride directly stimulates muscarinic receptors in the eye, causing contraction of the sphincter pupillae and ciliary muscle. This results in miosis and enhances aqueous humor outflow, thereby reducing intraocular pressure.

The dosing regimen is determined by the prescribing ophthalmologist based on the specific indication, disease severity, and patient response. The prescriber selects the appropriate concentration, volume, and frequency of intraocular administration.

Safety data for acetylcholine chloride in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with pilocarpine, another cholinergic miotic, acetylcholine chloride has a rapid onset when administered intraocularly and may be used where a short‑acting, directly administered agent is preferred. Both share similar mechanisms but differ in formulation and duration of action.

Store at ambient temperature, preferably below 25 °C, in the original sealed container. Protect from light, moisture and extreme temperature fluctuations. Do not freeze. Follow the label’s storage instructions and keep out of reach of children.

Miphtel is supplied as a sterile ophthalmic preparation for intraocular use. It is applied by a qualified eye‑care professional, typically as a drop or small volume injection directly onto the ocular surface or into the anterior chamber, according to the prescribed regimen.

Serious adverse events can include acute angle‑closure glaucoma, severe ocular inflammation, corneal edema, and systemic cholinergic toxicity such as bradycardia or hypotension. Prompt medical attention is required if any of these symptoms develop.

Patients with known hypersensitivity to acetylcholine chloride, those with narrow‑angle or uncontrolled glaucoma, and individuals taking anticholinergic eye medications should avoid Miphtel. Contra‑indications also include severe asthma or chronic obstructive pulmonary disease where cholinergic stimulation may exacerbate symptoms.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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