Product image of Mirabegron Glenmark (Mirabegron) supplied by GNH India

Mirabegron Glenmark

Active Ingredient:
Mirabegron
Origin:
EU

Mirabegron Glenmark (Mirabegron)

Mirabegron, the active ingredient in Mirabegron Glenmark, is a β3‑adrenergic receptor agonist presented as an oral tablet for oral use. It treats overactive bladder symptoms such as urgency, frequency and urge incontinence in adults.

GNH India supplies Mirabegron Glenmark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glenmark Arzneimittel Gmbh

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Indications & Clinical Uses

Mirabegron is used to manage overactive bladder, a condition characterized by urinary urgency, frequency, and incontinence.

  • Overactive bladder: improves bladder capacity and reduces urgency episodes.
  • Urinary urgency: lessens the intensity and frequency of sudden urges.
  • Urinary frequency: decreases the number of daytime voids.

How It Works

  • Mirabegron activates β3‑adrenergic receptors located in the detrusor smooth muscle of the bladder. Receptor activation stimulates cyclic AMP production, leading to relaxation of the bladder wall, increased functional capacity, and inhibition of involuntary contractions that cause urgency and frequency.

Side Effects

Common side effects are generally mild and may resolve with continued therapy.

Common Side Effects

  • Dry mouth
  • Constipation
  • Hypertension
  • Headache
  • Nasopharyngitis
  • Urinary tract infection

Serious or Rare Side Effects

  • Acute urinary retention
  • Severe hypertension
  • Tachycardia
  • Angioedema
  • Anaphylaxis
  • Renal impairment

Precautions & Warnings

Before prescribing mirabegron, clinicians should evaluate several safety factors.

  • Renal function: assess baseline renal function and adjust if necessary.
  • Hepatic impairment: use with caution in patients with severe liver disease.
  • Blood pressure: monitor regularly as mirabegron may increase systolic and diastolic pressure.
  • Drug interactions: review concomitant medications that affect adrenergic pathways.
  • Pregnancy and lactation: safety not established; avoid unless benefits outweigh risks.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original container.

Avoid Interactions

Mirabegron can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors: may increase mirabegron exposure.
  • Anticholinergic agents: combined effect may worsen urinary retention.
  • Nitrates: potential for additive hypotensive effect.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect blood pressure control.
  • Antihypertensives: monitor for additive blood pressure increase.
  • Warfarin: monitor INR as mirabegron may alter metabolism.

Frequently Asked Questions

Mirabegron Glenmark is prescribed to treat symptoms of overactive bladder, including urinary urgency, increased frequency of urination, and urge incontinence. By improving bladder storage capacity, it helps patients regain better control over their urinary habits and reduce disruptive episodes.

Mirabegron works by selectively activating β3‑adrenergic receptors in the detrusor muscle of the bladder. This activation raises cyclic AMP levels, causing smooth‑muscle relaxation, increased bladder capacity, and reduced involuntary contractions that trigger urgency and frequency.

The appropriate dose of mirabegron is determined by the prescribing clinician based on the patient’s medical condition, renal function, and response to therapy. The prescriber will select the starting dose and may adjust it during follow‑up visits to achieve optimal symptom control.

Safety data for mirabegron in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be avoided unless the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To order Mirabegron Glenmark, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirabegron belongs to a different therapeutic class than antimuscarinic agents. While antimuscarinics block muscarinic receptors and often cause dry mouth or constipation, mirabegron activates β3‑adrenergic receptors, typically resulting in a lower incidence of anticholinergic side effects but may raise blood pressure in some patients.

Store Mirabegron Glenmark at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

Mirabegron Glenmark is taken orally as a whole tablet, with or without food. Patients should swallow the tablet whole with water and follow the dosing schedule prescribed by their healthcare provider, typically once daily at the same time each day.

The most serious risks include acute urinary retention, severe hypertension, tachycardia, angioedema, anaphylactic reactions, and renal impairment. Patients should be educated to seek immediate medical attention if they experience difficulty urinating, a sudden rise in blood pressure, rapid heartbeat, swelling of the face or throat, or signs of kidney dysfunction.

Mirabegron is contraindicated in patients with uncontrolled hypertension, severe hepatic impairment, significant urinary retention, or known hypersensitivity to mirabegron or any of its excipients. Caution is also advised for individuals with moderate renal impairment or those taking medications that strongly inhibit CYP2D6.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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