Product image of Mirabegron Glenmark (Mirabegron) supplied by GNH India

Mirabegron Glenmark

Active Ingredient:
Mirabegron
Origin:
EU

Mirabegron Glenmark (Mirabegron)

Mirabegron, the active ingredient in Mirabegron Glenmark, is a β3‑adrenergic receptor agonist presented as a tablet for oral use. It treats overactive bladder symptoms such as urinary urgency, frequency and urge incontinence in adult patients.

GNH India supplies Mirabegron Glenmark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glenmark Pharmaceuticals S.R.O.

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Indications & Clinical Uses

Mirabegron is indicated for conditions affecting bladder storage function within the overactive bladder disease family.

  • Overactive bladder: reduces the number of urgency episodes and improves bladder capacity.
  • Urinary urgency: helps patients gain better control over sudden urges to void.
  • Urinary frequency: decreases daytime voiding frequency and improves quality of life.

How It Works

  • Mirabegron activates β3‑adrenergic receptors located on detrusor smooth muscle cells. Receptor activation stimulates cyclic AMP formation, leading to relaxation of the bladder wall during the storage phase. This relaxation increases functional bladder capacity and reduces involuntary contractions that cause urgency and frequency.

Side Effects

Adverse reactions may occur with Mirabegron therapy.

Common Side Effects

  • Headache
  • Hypertension
  • Nasopharyngitis
  • Urinary tract infection
  • Constipation
  • Dry mouth

Serious or Rare Side Effects

  • Urinary retention
  • Tachycardia or arrhythmia
  • Angioedema
  • Severe hypertension
  • Allergic skin reactions
  • Myocardial infarction

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Monitor blood pressure: check regularly, especially after dose changes.
  • Assess renal function: dose adjustment may be needed in impairment.
  • Review cardiovascular status: use caution in patients with arrhythmias.
  • Evaluate concomitant medications: watch for interactions with CYP2D6 substrates.
  • Avoid use in uncontrolled hypertension: contraindicated in severe cases.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Mirabegron can affect the pharmacokinetics of several co‑administered drugs.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine): may increase Mirabegron exposure.
  • Antihypertensive agents (e.g., β‑blockers): may reduce blood‑pressure‑lowering effect.
  • Digoxin: increased serum concentrations reported.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise Mirabegron levels.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may lower efficacy.
  • Diuretics: combined effect on blood pressure requires observation.

Frequently Asked Questions

Mirabegron Glenmark is prescribed to manage symptoms of overactive bladder, including urinary urgency, frequency, and urge incontinence. By relaxing the bladder’s detrusor muscle, it helps increase bladder capacity and reduces the need for frequent trips to the toilet.

The drug activates β3‑adrenergic receptors on the bladder’s smooth‑muscle cells. This activation raises cyclic AMP levels, leading to muscle relaxation during the storage phase, which expands functional bladder capacity and diminishes involuntary contractions that cause urgency.

The appropriate dose is determined by the prescribing clinician based on the patient’s condition, renal function, and blood‑pressure status. Dosage adjustments may be required for specific populations, and the prescriber will provide individualized instructions.

Safety data for Mirabegron in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Unlike antimuscarinics, which block muscarinic receptors, Mirabegron stimulates β3‑adrenergic receptors, offering a different mechanism that may result in fewer dry‑mouth and constipation side effects. Choice of therapy depends on patient tolerance, comorbidities and physician judgment.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Mirabegron Glenmark is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious adverse events can include significant hypertension, urinary retention, tachyarrhythmias, angioedema, and rare cases of myocardial infarction. Patients should be monitored for these conditions, and therapy should be discontinued if they occur.

Mirabegron is contraindicated in patients with uncontrolled hypertension, severe urinary retention, or known hypersensitivity to the drug. Caution is also advised for individuals with significant cardiovascular disease, severe renal impairment, or those taking strong CYP2D6 inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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