Product image of Mirabegron Heumann (Mirabegron) supplied by GNH India

Mirabegron Heumann

Active Ingredient:
Mirabegron
Origin:
EU

Mirabegron Heumann (Mirabegron)

Mirabegron, the active ingredient in Mirabegron Heumann, is a β3‑adrenergic receptor agonist presented as a tablet for oral use. It treats overactive bladder symptoms such as urinary urgency, frequency and urge incontinence in adults.

GNH India supplies Mirabegron Heumann as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Heumann Pharma Gmbh & Co. Generica Kg

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Indications & Clinical Uses

  • Mirabegron is a β3‑adrenergic receptor agonist used in the management of overactive bladder.
  • Overactive bladder: improves bladder storage capacity and reduces urgency episodes.
  • Urinary urgency: lessens the frequency of sudden urges to void.
  • Urge urinary incontinence: decreases episodes of involuntary leakage.
  • Urinary frequency: reduces the number of daytime voids.

How It Works

  • Mirabegron selectively activates β3‑adrenergic receptors located on the detrusor smooth muscle of the bladder. Activation leads to relaxation of the detrusor during the storage phase, thereby increasing functional bladder capacity and reducing involuntary contractions that cause urgency and incontinence.

Side Effects

Common Side Effects

  • Hypertension: elevated blood pressure may be observed.
  • Headache: mild to moderate headache is reported.
  • Nasopharyngitis: upper‑respiratory tract infection symptoms.
  • Constipation: reduced bowel motility.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or throat requiring urgent care.
  • Severe hypertension: markedly high blood pressure needing medical intervention.
  • Urinary retention: difficulty emptying the bladder that may need catheterisation.

Precautions & Warnings

  • Precautions should be observed before initiating therapy.
  • Monitor blood pressure: check regularly as Mirabegron can raise systolic values.
  • Assess cardiovascular status: use cautiously in patients with uncontrolled hypertension.
  • Evaluate renal function: dose may need adjustment in severe renal impairment.
  • Review concomitant medications: avoid strong CYP2D6 or CYP3A4 inhibitors where possible.
  • Store at ambient temperature: keep below 25°C, retain in the original pack and protect from moisture.

Avoid Interactions

Potential drug interactions require careful review.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors: may increase Mirabegron exposure (e.g., fluoxetine, paroxetine).
  • Potent CYP3A4 inhibitors: can raise plasma levels (e.g., ketoconazole, itraconazole).
  • Other β3‑adrenergic agonists: additive pharmacologic effect.

Moderate Interactions (Monitor Closely)

  • Diuretics: may amplify blood‑pressure changes.
  • Antihypertensive agents: dose adjustments may be needed.
  • NSAIDs: concurrent use can increase risk of hypertension.

Frequently Asked Questions

Mirabegron Heumann is prescribed for adults with overactive bladder, including symptoms such as urinary urgency, increased frequency, and urge urinary incontinence. It helps increase bladder capacity and reduce involuntary contractions.

The drug selectively activates β3‑adrenergic receptors on the detrusor muscle of the bladder. This activation relaxes the muscle during the storage phase, allowing the bladder to hold more urine and decreasing episodes of urgency and leakage.

The specific dose and titration schedule are determined by the prescribing clinician based on the patient’s condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Mirabegron in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Mirabegron belongs to a different class (β3‑adrenergic agonist) and works by relaxing bladder muscle rather than blocking muscarinic receptors. It may be preferred when anticholinergics cause dry mouth, constipation, or cognitive side effects, but individual response varies.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Mirabegron Heumann is taken orally as a tablet, usually once daily with or without food. The exact timing and whether it is taken with meals should follow the prescriber’s guidance.

Serious risks include significant hypertension, angioedema, and urinary retention. Patients should be educated to seek immediate medical attention if they experience severe headache, swelling of the face or throat, or inability to urinate.

Individuals with uncontrolled hypertension, severe renal impairment, or known hypersensitivity to Mirabegron should avoid the medication. It is also contraindicated when used together with strong CYP2D6 or CYP3A4 inhibitors that cannot be discontinued.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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