Product image of Mirabegron Stada (Mirabegron) supplied by GNH India

Mirabegron Stada

Active Ingredient:
Mirabegron
Origin:
EU

Mirabegron Stada (Mirabegron)

Mirabegron, the active ingredient in Mirabegron Stada, is a Beta-3 adrenergic agonist presented as an oral dosage form for oral use. It is indicated for the management of overactive bladder symptoms such as urgency, frequency and urge incontinence in adult patients.

GNH India supplies Mirabegron Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Gmbh

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Indications & Clinical Uses

Mirabegron acts on the bladder’s β3‑adrenergic receptors to improve storage symptoms in overactive bladder and related conditions.

  • Overactive bladder: increases bladder capacity and reduces urgency episodes.
  • Urinary urgency: lessens the sudden need to void.
  • Urinary frequency: decreases the number of daily voids.
  • Urge urinary incontinence: lowers the incidence of involuntary leakage.

How It Works

  • Mirabegron selectively stimulates β3‑adrenergic receptors in the detrusor smooth muscle of the bladder. Activation of these receptors raises intracellular cyclic AMP, leading to relaxation of the detrusor muscle during the storage phase, thereby increasing functional bladder capacity and reducing involuntary contractions that cause urgency and incontinence.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Hypertension: elevated blood pressure observed in some patients.
  • Nasopharyngitis: mild upper respiratory tract infection symptoms.
  • Headache: transient head pain of varying intensity.
  • Constipation: reduced bowel motility leading to hard stools.

Serious or Rare Side Effects

  • Severe hypertension: marked increase in blood pressure requiring medical intervention.
  • Urinary retention: difficulty emptying the bladder that may need catheterisation.
  • Angle‑closure glaucoma: acute increase in intra‑ocular pressure presenting with eye pain and visual disturbance.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Monitor blood pressure: check baseline and periodic readings.
  • Assess renal function: dose adjustment may be needed in impairment.
  • Review concomitant medications: especially other agents affecting bladder tone.
  • Use caution in uncontrolled hypertension: avoid if systolic >180 mmHg.
  • Avoid in severe hepatic impairment: limited data on safety.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Mirabegron can affect the pharmacokinetics of several co‑administered drugs.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors (e.g., paroxetine): may increase mirabegron exposure.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole): can raise plasma levels.
  • Combined anticholinergics: may exacerbate urinary retention.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypotensive effect when blood pressure falls.
  • Antihypertensives: monitor for additive blood‑pressure lowering.
  • Other β3‑agonists: concurrent use may increase risk of cardiovascular effects.

Frequently Asked Questions

Mirabegron Stada is prescribed to treat symptoms of overactive bladder, including urinary urgency, increased frequency of urination, and urge urinary incontinence. It helps patients achieve better bladder control by increasing the bladder’s storage capacity.

Mirabegron selectively activates β3‑adrenergic receptors in the detrusor muscle of the bladder. This activation raises cyclic AMP levels, causing the muscle to relax during the storage phase, which expands bladder capacity and reduces involuntary contractions that trigger urgency and leakage.

The appropriate dose of Mirabegron Stada is determined by the prescribing healthcare professional based on the patient’s medical condition, renal function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of Mirabegron Stada in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike anticholinergics, which block muscarinic receptors and may cause dry mouth or constipation, Mirabegron works by stimulating β3‑adrenergic receptors, offering an alternative mechanism with a different side‑effect profile. Choice of therapy depends on patient tolerance, comorbidities and physician judgment.

Mirabegron Stada should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Do not store in bathrooms or near heat sources, and keep the container tightly closed when not in use.

Mirabegron Stada is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious risks include significant hypertension, urinary retention that may require catheterisation, and rare cases of angle‑closure glaucoma. Patients should be educated to report sudden increases in blood pressure, difficulty emptying the bladder, or eye pain promptly.

Mirabegron Stada is contraindicated in patients with uncontrolled hypertension, severe hepatic impairment, or known hypersensitivity to mirabegron or any excipients. It should also be avoided in individuals taking strong CYP2D6 or CYP3A4 inhibitors without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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