Product image of Mirabegron Stada (Mirabegron) supplied by GNH India

Mirabegron Stada

Active Ingredient:
Mirabegron
Origin:
EU

Mirabegron Stada (Mirabegron)

Mirabegron, the active ingredient in Mirabegron Stada, is a β3‑adrenergic receptor agonist presented as an oral tablet for oral use. It is indicated for the treatment of overactive bladder symptoms such as urinary urgency, frequency and urge incontinence in adults.

GNH India supplies Mirabegron Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for healthcare providers across multiple regions. Its distribution network ensures timely delivery and regulatory compliance for each shipment.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Mirabegron is used to manage symptoms of overactive bladder, a condition characterized by involuntary bladder contractions.

  • Overactive bladder: reduces urgency episodes and increases bladder capacity.
  • Urinary urgency: lessens the sudden need to void.
  • Urinary frequency: decreases the number of daily voids.
  • Urge urinary incontinence: helps prevent involuntary leakage.

How It Works

  • Mirabegron selectively stimulates β3‑adrenergic receptors located in the detrusor smooth muscle of the bladder. Activation of these receptors triggers cyclic AMP accumulation, leading to relaxation of the detrusor muscle, increased bladder storage capacity, and a reduction in involuntary contractions that cause urgency and incontinence.

Side Effects

Mirabegron may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Hypertension: elevated blood pressure readings.
  • Headache: mild to moderate intensity.
  • Nasopharyngitis: common cold‑like symptoms.
  • Urinary retention: difficulty initiating urination.
  • Dry mouth: reduced salivation.
  • Constipation: infrequent bowel movements.

Serious or Rare Side Effects

  • Severe hypertension: markedly high blood pressure requiring medical attention.
  • Tachycardia: rapid heart rate that may be symptomatic.
  • Angioedema: swelling of face, lips, or throat.
  • Acute urinary retention: sudden inability to void.
  • QT interval prolongation: potential cardiac rhythm disturbance.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Monitor blood pressure: check regularly as mirabegron can increase systolic and diastolic values.
  • Assess renal function: dose may need adjustment in severe impairment.
  • Avoid in uncontrolled hypertension: contraindicated due to cardiovascular risk.
  • Caution in narrow‑angle glaucoma: may exacerbate intra‑ocular pressure.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs potential risk.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Mirabegron can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors: may increase mirabegron plasma concentrations.
  • Antihypertensives (β‑blockers): additive blood‑pressure‑lowering effects.
  • QT‑prolonging drugs: heightened risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Diuretics: may alter urinary symptom control.
  • Other β3‑agonists: additive bladder‑relaxant effect.
  • Nitrates: monitor for potential hypotension.

Frequently Asked Questions

Mirabegron Stada is prescribed for adults with overactive bladder, specifically to reduce urinary urgency, frequency, and urge incontinence. It helps increase bladder capacity by relaxing the detrusor muscle, thereby improving daily urinary control.

Mirabegron selectively activates β3‑adrenergic receptors in the bladder’s detrusor muscle. This activation raises cyclic AMP levels, leading to muscle relaxation, increased storage capacity, and fewer involuntary contractions that cause urgency and leakage.

The appropriate dose of Mirabegron Stada is determined by the prescribing healthcare professional based on the patient’s condition, renal function, and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for mirabegron in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Mirabegron Stada, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mirabegron offers an alternative mechanism by targeting β3‑adrenergic receptors, whereas antimuscarinics block muscarinic receptors. This difference can result in a lower incidence of dry mouth and constipation, but individual response and side‑effect profiles vary, so clinicians choose based on patient tolerance and comorbidities.

Mirabegron Stada tablets should be stored at ambient temperature below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Mirabegron Stada is taken orally, usually once daily with or without food, as directed by the prescriber. Swallow the tablet whole with water; do not crush, split, or chew unless specifically instructed.

Serious risks include significant hypertension, tachycardia, acute urinary retention, angioedema, and rare cardiac arrhythmias such as QT prolongation. Patients should report any sudden increase in blood pressure, rapid heartbeat, difficulty urinating, or swelling of the face or throat immediately.

Mirabegron Stada is contraindicated in patients with uncontrolled hypertension, severe renal impairment, or known hypersensitivity to mirabegron or any tablet excipients. Caution is also advised for individuals with narrow‑angle glaucoma or those taking medications that significantly affect blood pressure or cardiac rhythm.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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