Product image of Mirabegron Stada (Mirabegron) supplied by GNH India

Mirabegron Stada

Active Ingredient:
Mirabegron
Origin:
EU

Mirabegron Stada (Mirabegron)

Mirabegron, the active ingredient in Mirabegron Stada, is a β3‑adrenergic receptor agonist presented as an oral dosage form for oral use. It treats overactive bladder symptoms such as urgency, frequency and urge incontinence in adult patients.
GNH India supplies Mirabegron Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Mirabegron is a β3‑adrenergic receptor agonist used in the management of overactive bladder and related lower urinary tract symptoms.

  • Overactive bladder: improves bladder capacity and reduces urgency episodes.
  • Urinary urgency: decreases the frequency of sudden urges to void.
  • Urinary frequency: lowers the number of daytime voids.
  • Urge urinary incontinence: lessens episodes of involuntary leakage.

How It Works

  • Mirabegron selectively stimulates β3‑adrenergic receptors in the detrusor smooth muscle of the bladder. Activation of these receptors increases cyclic AMP levels, leading to relaxation of the detrusor muscle during the storage phase, which expands functional bladder capacity and diminishes involuntary contractions that cause urgency and incontinence.

Side Effects

Adverse reactions have been reported with mirabegron use.

Common Side Effects

  • Hypertension: elevated blood pressure readings.
  • Nasopharyngitis: mild upper respiratory tract infection symptoms.
  • Headache: persistent or intermittent head pain.
  • Dry mouth: reduced salivation.
  • Constipation: decreased bowel movements.
  • Urinary retention: difficulty initiating or completing urination.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue or throat.
  • Severe hypertension: markedly high blood pressure requiring medical intervention.
  • Acute urinary retention requiring catheterisation.
  • Allergic reactions: rash, pruritus, or anaphylaxis.
  • Myocardial infarction: rare cardiac events.

Precautions & Warnings

Mirabegron should be used with attention to several safety considerations.

  • Blood pressure monitoring: check baseline and periodic readings.
  • Renal function assessment: evaluate creatinine clearance before initiation.
  • Urinary retention risk: assess for pre‑existing obstruction.
  • Uncontrolled hypertension: avoid use in patients with severe hypertension.
  • Concomitant anticholinergics: monitor for additive urinary retention.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mirabegron may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase mirabegron exposure.
  • Strong CYP2D6 inhibitors (e.g., paroxetine): may raise plasma concentrations.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrate drugs (e.g., metoprolol): reduced efficacy may occur.
  • Antihypertensive agents: possible attenuation of blood‑pressure‑lowering effect.
  • Diuretics: may enhance risk of hypertension.
  • NSAIDs: can contribute to blood‑pressure elevation.

Frequently Asked Questions

Mirabegron Stada is prescribed for adults with overactive bladder, including symptoms such as urinary urgency, increased frequency of daytime voids, and urge urinary incontinence. It helps increase bladder capacity and reduce the frequency of involuntary contractions.

Mirabegron selectively activates β3‑adrenergic receptors located in the detrusor smooth muscle of the bladder. This activation raises cyclic AMP levels, causing the muscle to relax during the storage phase, which expands bladder capacity and lessens urgency and leakage.

The specific dose of Mirabegron Stada is determined by the prescribing healthcare professional based on the patient’s medical condition, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for mirabegron in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To request Mirabegron Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Mirabegron belongs to a different class (β3‑adrenergic agonist) than anticholinergics. While anticholinergics block muscarinic receptors, mirabegron relaxes detrusor muscle via β3‑receptor stimulation. This distinction can result in a different side‑effect profile, with mirabegron often causing less dry mouth and constipation but potentially raising blood pressure.

Mirabegron Stada should be stored below 25 °C (77 °F) in its original container, protected from moisture and direct sunlight. Do not store in a bathroom or near a heat source, and keep the product out of reach of children.

Mirabegron Stada is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or split unless specifically instructed.

Serious risks include significant hypertension, angioedema, acute urinary retention that may require catheterisation, and rare cardiovascular events such as myocardial infarction. Patients should seek immediate medical attention if they experience severe headache, swelling of the face or throat, or inability to urinate.

Mirabegron Stada is contraindicated in patients with uncontrolled hypertension, severe urinary retention, or known hypersensitivity to mirabegron or any of its excipients. Caution is also advised for individuals with significant cardiovascular disease or those taking strong CYP3A4 or CYP2D6 inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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