Product image of Mirabegron Teva (Mirabegron) supplied by GNH India

Mirabegron Teva

Active Ingredient:
Mirabegron
Origin:
EU

Mirabegron Teva (Mirabegron)

Mirabegron, the active ingredient in Mirabegron Teva, is a β3‑adrenergic receptor agonist presented as an oral dosage form for oral use. It treats overactive bladder symptoms such as urgency, frequency, and urge incontinence in adult patients.

GNH India supplies Mirabegron Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Its global distribution network ensures timely delivery and compliance with local regulatory requirements.

Manufacturer / TM Owner

Teva Pharmaceuticals Cr, S.R.O.

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Indications & Clinical Uses

Mirabegron is indicated for conditions within the overactive bladder disease spectrum, improving bladder storage function.

  • Overactive bladder: increases bladder capacity and reduces urgency episodes.
  • Urinary urgency: lessens the frequency of sudden urges to void.
  • Urinary frequency: decreases the number of daytime voids.
  • Urge urinary incontinence: reduces episodes of involuntary leakage.

How It Works

  • Mirabegron selectively stimulates β3‑adrenergic receptors located on detrusor smooth muscle. Activation of these receptors raises intracellular cyclic adenosine monophosphate (cAMP), leading to relaxation of the detrusor during the storage phase of the micturition cycle. The resulting reduction in bladder muscle tone expands functional bladder capacity, diminishes involuntary contractions, and improves overall urinary storage efficiency.

Side Effects

Mirabegron may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hypertension: increase in blood pressure observed in some patients.
  • Nasopharyngitis: mild upper respiratory tract infection symptoms.
  • Headache: transient head pain of varying intensity.
  • Constipation: reduced bowel movements or hard stools.

Serious or Rare Side Effects

  • Urinary retention: difficulty emptying the bladder requiring medical attention.
  • Severe hypertension: markedly elevated blood pressure that may need intervention.
  • Tachycardia: rapid heart rate potentially symptomatic.
  • Angioedema: swelling of face, lips, tongue or airway demanding urgent care.

Precautions & Warnings

Before initiating Mirabegron therapy, clinicians should evaluate several safety considerations.

  • Monitor blood pressure: check baseline and periodic measurements.
  • Assess renal function: adjust use in patients with severe impairment.
  • Avoid use in uncontrolled hypertension: risk of further blood pressure rise.
  • Use caution in the elderly: increased susceptibility to adverse effects.
  • Review concomitant medications: consider potential drug interactions.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Mirabegron can affect the pharmacokinetics of other medicines, requiring attention to interaction risk levels.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors: may increase mirabegron plasma concentrations.
  • Strong CYP3A4 inhibitors: can raise exposure and heighten side‑effect risk.
  • Anticholinergic agents: may diminish therapeutic benefit on bladder symptoms.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypertension when combined.
  • Antihypertensives: mirabegron may attenuate their blood‑pressure‑lowering effect.
  • Warfarin: monitor INR as mirabegron can alter anticoagulant activity.

Frequently Asked Questions

Mirabegron Teva is prescribed to manage symptoms of overactive bladder, including urinary urgency, increased frequency of urination, and urge urinary incontinence. By improving bladder storage capacity, it helps patients achieve better control over bladder function and reduces the need for frequent bathroom trips.

Mirabegron works by selectively activating β3‑adrenergic receptors on the detrusor muscle of the bladder. This activation raises intracellular cAMP levels, causing the muscle to relax during the storage phase of the urinary cycle, which expands bladder capacity and reduces involuntary contractions.

The appropriate dose of Mirabegron is determined by the prescribing healthcare professional based on the individual’s clinical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for Mirabegron during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare provider.

To place an order, submit an enquiry on the Mirabegron Teva product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirabegron belongs to a different therapeutic class (β3‑adrenergic agonist) than antimuscarinic drugs. While both aim to reduce overactive bladder symptoms, Mirabegron does not carry the anticholinergic side‑effects such as dry mouth and constipation that are common with antimuscarinics, offering an alternative for patients who cannot tolerate those agents.

Mirabegron tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use it after the expiry date indicated on the label.

Mirabegron is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not crushed or chewed, unless otherwise directed by a healthcare professional.

Serious risks include significant hypertension, urinary retention that may require catheterisation, and rare but severe allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience a sudden rise in blood pressure, inability to empty the bladder, or swelling of the face, lips, tongue or throat.

Mirabegron is contraindicated in patients with uncontrolled hypertension, severe hepatic impairment, or known hypersensitivity to the drug. Caution is also advised for individuals with moderate renal impairment, narrow‑angle glaucoma, or those taking medications that strongly inhibit CYP2D6 or CYP3A4 without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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