Product image of Mirabegron Zentiva (Mirabegron) supplied by GNH India

Mirabegron Zentiva

Active Ingredient:
Mirabegron
Origin:
EU

Mirabegron Zentiva (Mirabegron)

Mirabegron, the active ingredient in Mirabegron Zentiva, is a β3‑adrenergic receptor agonist presented as an oral tablet for oral use. It treats overactive bladder symptoms such as urinary urgency, frequency and incontinence in adult patients by relaxing the detrusor muscle and increasing bladder capacity.

GNH India supplies Mirabegron Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Mirabegron is indicated for conditions within the overactive bladder spectrum, where it helps control urinary symptoms.

  • Overactive bladder: reduces urgency episodes and increases bladder storage capacity.
  • Urinary urgency: lessens the sudden need to void, improving daily activities.
  • Urinary frequency: decreases the number of daytime voids, enhancing quality of life.
  • Urge urinary incontinence: improves continence by reducing involuntary bladder contractions.

How It Works

  • Mirabegron activates β3‑adrenergic receptors located on the detrusor smooth‑muscle of the bladder. This activation triggers a cascade that relaxes the muscle, thereby increasing functional bladder capacity and reducing involuntary contractions that cause urgency and frequency.

Side Effects

Like all medicines, Mirabegron may be associated with adverse reactions that vary in frequency and severity.

Common Side Effects

  • Dry mouth
  • Increased blood pressure
  • Nasopharyngitis
  • Headache

Serious or Rare Side Effects

  • Severe hypertension
  • Urinary retention
  • Angle‑closure glaucoma

Precautions & Warnings

When prescribing Mirabegron, clinicians should consider several safety and handling precautions.

  • Blood pressure monitoring: check baseline and periodically during therapy.
  • Cardiovascular disease: use cautiously in patients with uncontrolled hypertension or heart failure.
  • Drug interactions: review concomitant medications that affect adrenergic pathways.
  • Renal or hepatic impairment: dose adjustment may be required based on clinical judgment.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Mirabegron can affect the plasma concentrations of other drugs, requiring attention to potential interactions.

Major Interactions (Avoid)

  • Metoprolol: may reduce beta‑blocker efficacy, leading to increased heart rate.
  • CYP2D6 substrates (e.g., desipramine): plasma levels may rise, increasing toxicity risk.

Moderate Interactions (Monitor Closely)

  • Anticholinergics: additive effect on urinary retention.
  • Diuretics: may enhance hypotensive effect.
  • Warfarin: monitor INR as interaction potential exists.

Frequently Asked Questions

Mirabegron Zentiva is prescribed to manage symptoms of overactive bladder, including urinary urgency, frequency, and urge incontinence. By increasing bladder capacity, it helps reduce the number of involuntary voiding episodes in adult patients.

The drug activates β3‑adrenergic receptors on the bladder’s detrusor muscle. This activation relaxes the muscle, allowing the bladder to hold more urine and decreasing the frequency of involuntary contractions that cause urgency.

The dosage of Mirabegron is individualized by the prescribing clinician based on the patient’s condition, renal and hepatic function, and response to therapy. The prescriber determines the appropriate strength and titration schedule.

Safety data for Mirabegron during pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirabegron belongs to a different class (β3‑adrenergic agonist) and does not have the anticholinergic side‑effects such as dry mouth and constipation that are common with antimuscarinic drugs. It may be used alone or in combination with antimuscarinics for patients who need additional symptom control.

Store Mirabegron tablets at ambient temperature, preferably below 25 °C. Keep the product in its original blister pack, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Mirabegron is taken orally, usually as a whole tablet swallowed with water. It is generally taken once daily, with or without food, as directed by the prescribing clinician.

Patients should be alert for severe hypertension, urinary retention that may require catheterisation, and signs of angle‑closure glaucoma such as eye pain, blurred vision, or halos around lights. Any of these symptoms warrant immediate medical attention.

Mirabegron is contraindicated in individuals with uncontrolled hypertension, severe hepatic impairment, or known hypersensitivity to the drug. Caution is also advised for patients with a history of urinary retention or narrow‑angle glaucoma.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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