Product image of Mirabegron Zentiva (Mirabegron) supplied by GNH India

Mirabegron Zentiva

Active Ingredient:
Mirabegron
Origin:
EU

Mirabegron Zentiva (Mirabegron)

Mirabegron, the active ingredient in Mirabegron Zentiva, is a β3‑adrenergic receptor agonist presented as a tablet for oral use. It treats overactive bladder symptoms such as urgency, frequency and urge incontinence in adults.

GNH India supplies Mirabegron Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Mirabegron is indicated for conditions related to overactive bladder, a disorder of detrusor muscle activity.

  • Overactive bladder: reduces urinary urgency and frequency, increasing bladder capacity.
  • Urinary urgency: alleviates sudden strong need to void.
  • Urinary frequency: decreases the number of daytime voids.

How It Works

  • Mirabegron activates β3‑adrenergic receptors located in the detrusor smooth muscle of the urinary bladder. Receptor activation stimulates cyclic AMP production, leading to relaxation of the detrusor muscle during the storage phase, which increases functional bladder capacity and reduces involuntary contractions that cause urgency and frequency.

Side Effects

Common Side Effects

  • Hypertension: elevated blood pressure observed in some patients.
  • Nasopharyngitis: mild upper respiratory tract infection symptoms.
  • Headache: transient head pain.
  • Constipation: reduced bowel movements.
  • Dry mouth: decreased salivation.
  • Urinary tract infection: mild infection symptoms.

Serious or Rare Side Effects

  • Urinary retention: difficulty emptying the bladder.
  • Severe hypertension: markedly high blood pressure requiring medical attention.
  • Tachycardia: rapid heart rate.
  • Angioedema: swelling of face, lips or throat.
  • Anaphylaxis: rare severe allergic reaction.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess blood pressure: monitor baseline and periodic readings.
  • Review renal function: adjust use in severe impairment.
  • Avoid in uncontrolled hypertension: contraindicated.
  • Caution in elderly: may be more sensitive to adverse effects.
  • Evaluate concomitant medications: potential for interactions.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Mirabegron may interact with several drug classes; review patient medication lists.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors: may increase mirabegron exposure and risk of side effects.
  • Antihypertensive agents: additive blood‑pressure‑lowering effects can cause hypotension.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect fluid balance and blood pressure.
  • Other β‑adrenergic agents: potential additive cardiovascular effects.
  • Anticholinergics: may reduce the therapeutic benefit of mirabegron.

Frequently Asked Questions

Mirabegron Zentiva is prescribed to manage symptoms of overactive bladder, including urinary urgency, increased frequency of daytime voids, and urge incontinence. By improving bladder storage capacity, it helps patients achieve better control over their urinary habits.

Mirabegron selectively stimulates β3‑adrenergic receptors in the detrusor muscle of the bladder. Activation raises cyclic AMP levels, causing the muscle to relax during the filling phase, which expands bladder capacity and reduces involuntary contractions that trigger urgency.

The dosage of Mirabegron Zentiva is determined by the prescribing healthcare professional based on the individual’s clinical condition, renal function and concomitant therapies. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Mirabegron in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirabegron belongs to a different class (β3‑adrenergic agonist) than antimuscarinics such as oxybutynin. It generally has a lower incidence of dry mouth and constipation, but may raise blood pressure. Choice of therapy depends on patient tolerance, comorbidities and physician preference.

Mirabegron Zentiva tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and heat. Keep the container tightly closed and out of direct sunlight.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious adverse events include significant hypertension, urinary retention, tachycardia, angioedema and rare cases of anaphylaxis. Patients should seek immediate medical attention if they experience severe headache, rapid heartbeat, difficulty urinating or swelling of the face or throat.

Mirabegron is contraindicated in patients with uncontrolled hypertension, severe renal impairment, or known hypersensitivity to mirabegron or any tablet excipients. Caution is also advised for individuals with a history of urinary retention or cardiac arrhythmias.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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