Product image of Mirabegron Zentiva (Mirabegron) supplied by GNH India

Mirabegron Zentiva

Active Ingredient:
Mirabegron
Origin:
EU

Mirabegron Zentiva (Mirabegron)

Mirabegron, the active ingredient in Mirabegron Zentiva, is a Beta-3 adrenergic receptor agonist presented as an oral dosage form for oral use. It treats overactive bladder symptoms such as urgency, frequency, and urge urinary incontinence in adults.

GNH India supplies Mirabegron Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva France

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Indications & Clinical Uses

Mirabegron is used to manage overactive bladder, a condition characterized by urinary urgency and frequency.

  • Overactive bladder: increases bladder capacity and reduces urgency episodes.
  • Urinary urgency: lessens the frequency of sudden urges to void.
  • Urge urinary incontinence: decreases episodes of involuntary leakage.

How It Works

  • Mirabegron selectively activates β3‑adrenergic receptors located in the detrusor smooth muscle of the bladder. This activation leads to relaxation of the detrusor muscle, allowing the bladder to store larger volumes of urine and reducing involuntary contractions that cause urgency and incontinence.

Side Effects

Adverse reactions may occur with mirabegron therapy.

Common Side Effects

  • Hypertension
  • Nasopharyngitis
  • Urinary tract infection
  • Headache
  • Constipation
  • Dry mouth

Serious or Rare Side Effects

  • Severe hypertension
  • Urinary retention
  • Tachycardia
  • Angioedema
  • Myocardial infarction
  • Anaphylaxis

Precautions & Warnings

Before initiating mirabegron, several safety considerations should be reviewed.

  • Monitor blood pressure: check baseline and periodically during therapy.
  • Assess renal function: adjust use in patients with severe impairment.
  • Review cardiovascular history: use cautiously in patients with arrhythmias.
  • Evaluate for drug interactions: avoid concomitant strong CYP2D6 inhibitors.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Mirabegron may interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors: can increase mirabegron exposure.
  • Antihypertensive agents: additive blood‑pressure‑lowering effects.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect blood‑pressure control.
  • Anticholinergic agents: may reduce overall efficacy for overactive bladder.
  • CYP3A4 inducers: may lower mirabegron plasma concentrations.

Frequently Asked Questions

Mirabegron Zentiva is prescribed to manage symptoms of overactive bladder, including urinary urgency, frequency, and urge urinary incontinence. By improving bladder storage capacity, it helps patients achieve better control over urinary habits.

Mirabegron selectively stimulates β3‑adrenergic receptors in the bladder’s detrusor muscle. This activation relaxes the muscle, allowing the bladder to hold more urine and reducing involuntary contractions that cause urgency and leakage.

The dose of mirabegron is individualized by the prescribing clinician based on the patient’s condition, renal function, and response to therapy. The prescriber determines the appropriate strength and dosing schedule.

Safety data for mirabegron during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirabegron belongs to a different class (β3‑adrenergic agonist) than antimuscarinic drugs. It does not carry the anticholinergic side‑effects such as dry mouth and constipation, and may be used alone or in combination with antimuscarinics for patients who need additional symptom control.

Store the product at room temperature, below 25 °C, in the original packaging. Protect it from moisture, excessive heat and direct sunlight to maintain stability and potency.

Mirabegron Zentiva is taken orally, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious adverse events include severe hypertension, urinary retention, tachycardia, angioedema, myocardial infarction and anaphylaxis. Patients should seek immediate medical attention if they experience any of these symptoms.

Mirabegron is contraindicated in patients with uncontrolled hypertension, severe hepatic impairment, or known hypersensitivity to mirabegron or any of its excipients. Caution is also advised for individuals with significant cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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