Product image of Mirataz (Mirtazapine) supplied by GNH India

Mirataz

Active Ingredient:
Mirtazapine
Brand:
Mirataz
Origin:
European Union

Mirataz (Mirtazapine)

Mirtazapine, the active ingredient in Mirataz, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as a veterinary oral formulation for use in cats. It is employed to stimulate appetite in feline patients experiencing weight loss or reduced food intake. It is indicated for cats with conditions such as chronic kidney disease, hyperthyroidism, or any illness causing anorexia.

GNH India supplies Mirataz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, veterinary clinics, specialty pharmacies, and research institutions worldwide, ensuring quality and regulatory compliance.

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Indications & Clinical Uses

Mirtazapine acts on central adrenergic and serotonergic pathways to increase appetite in feline patients.

  • Appetite stimulation in cats: increases food intake in cats with anorexia.
  • Weight loss management in cats: helps maintain body condition in cats with chronic disease.
  • Pre‑operative preparation in cats: improves nutritional status before surgery.
  • Renal disease‑associated cachexia: supports caloric intake in cats with chronic kidney disease.
  • Cancer‑associated anorexia: aids in maintaining nutrition in cats with neoplasia.

How It Works

  • Mirtazapine antagonizes central α2‑adrenergic receptors and blocks 5‑HT2 and 5‑HT3 serotonin receptors. This dual action disinhibits norepinephrine release and enhances serotonergic transmission, leading to increased appetite and weight gain in treated animals.

Side Effects

Mirtazapine may cause a range of adverse reactions in cats.

Common Side Effects

  • Sedation: mild to moderate drowsiness after dosing.
  • Increased appetite: marked rise in food consumption.
  • Weight gain: gradual increase in body mass.
  • Gastrointestinal upset: occasional vomiting or soft stools.
  • Ataxia: transient incoordination in some cats.

Serious or Rare Side Effects

  • Severe hypersensitivity: rash, facial swelling, or anaphylaxis.
  • Neutropenia: marked reduction in white blood cells.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Seizures: rare occurrence of convulsive activity.
  • Cardiac arrhythmias: abnormal heart rhythms in predisposed animals.

Precautions & Warnings

When using Mirataz, veterinarians should consider several safety measures.

  • Monitor body weight: track changes regularly to avoid excessive gain.
  • Assess liver function: obtain baseline hepatic enzymes before treatment.
  • Use caution in cardiac disease: monitor heart rate and rhythm.
  • Avoid in cats with known hypersensitivity to mirtazapine.
  • Observe for behavioral changes: report excessive sedation or aggression.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Mirtazapine can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • CYP1A2 inhibitors: may increase mirtazapine plasma levels.
  • CYP2D6 inhibitors: can raise exposure and risk of toxicity.
  • Other serotonergic agents: heightened risk of serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • CNS depressants: additive sedation may occur.
  • Anticholinergic drugs: may worsen constipation.
  • Diuretics: monitor electrolytes and hydration status.

Frequently Asked Questions

Mirataz is a veterinary formulation of mirtazapine indicated to stimulate appetite in cats. It is commonly prescribed for feline patients that are not eating adequately due to chronic illness, weight loss, or conditions such as kidney disease, hyperthyroidism, or cancer‑related anorexia.

Mirtazapine blocks central α2‑adrenergic receptors and antagonizes 5‑HT2 and 5‑HT3 serotonin receptors. By inhibiting these pathways, it releases norepinephrine and serotonin, neurotransmitters that promote hunger signals in the brain, leading to increased food intake and weight gain in cats.

The appropriate dose of Mirataz is determined by the prescribing veterinarian based on the cat’s weight, health status, and clinical response. Dosage regimens may vary, and owners should follow the specific instructions provided by the animal health professional.

Safety data for mirtazapine in pregnant or lactating cats are limited. Veterinarians generally exercise caution and weigh potential benefits against unknown risks. If use is considered essential, close monitoring and veterinary guidance are recommended.

To request Mirataz, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Mirataz (mirtazapine) differs from older agents such as cyproheptadine by targeting both adrenergic and serotonergic pathways, often resulting in a more pronounced appetite boost with fewer anticholinergic side effects. Its safety profile and rapid onset make it a preferred choice for many veterinarians, though individual response can vary.

Mirataz should be stored at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed when not in use.

Mirataz is given orally, typically as a tablet or liquid formulation, according to the veterinarian’s instructions. It can be placed directly in the mouth or mixed with a small amount of food to ensure complete ingestion.

Serious adverse events, although rare, include severe hypersensitivity reactions (rash, facial swelling, anaphylaxis), neutropenia, hepatic dysfunction, seizures, and cardiac arrhythmias. Owners should seek immediate veterinary care if any of these signs appear.

Cats with a known hypersensitivity to mirtazapine or any of its excipients should not receive Mirataz. Additionally, animals with uncontrolled cardiac disease, severe liver impairment, or those receiving contraindicated serotonergic drugs should be evaluated carefully before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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