Product image of Mirena (Levonorgestrel) supplied by GNH India

Mirena

Active Ingredient:
Levonorgestrel
Origin:
EU

Mirena (Levonorgestrel)

Levonorgestrel, the active ingredient in Mirena, is a progestin presented as a 20 µg/day levonorgestrel‑releasing intrauterine system for intrauterine use. It provides long‑term contraception and can lessen heavy menstrual bleeding in women of reproductive age through hormonal modulation of the endometrium and cervical mucus.

GNH India supplies Mirena as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance and reliable global logistics and patient safety.

Manufacturer / TM Owner

Bayer Doo

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Indications & Clinical Uses

Mirena (levonorgestrel intrauterine system) is used in hormonal contraceptive and menstrual‑management pathways.

  • Contraception: provides up to five years of highly effective pregnancy prevention.
  • Heavy menstrual bleeding: reduces menstrual blood loss and may improve anemia.
  • Endometriosis‑associated pain: alleviates dysmenorrhea and pelvic pain linked to endometriosis.

How It Works

  • Levonorgestrel released from the intrauterine system acts locally on the uterine lining and cervical canal. It binds to progesterone receptors, suppressing endometrial proliferation, thickening cervical mucus to impede sperm passage, and in some users may inhibit ovulation. The localized delivery maintains effective concentrations in the uterus while minimizing systemic exposure.

Side Effects

Adverse reactions to Mirena are reported with varying frequency.

Common Side Effects

  • Irregular bleeding or spotting: unpredictable bleeding patterns, especially during the first months.
  • Decreased menstrual flow or amenorrhea: reduced periods or absence of bleeding.
  • Headache: mild to moderate intensity.
  • Breast tenderness: discomfort or soreness in the breasts.
  • Mood changes: irritability or mood swings.
  • Abdominal or pelvic pain: cramping or discomfort.

Serious or Rare Side Effects

  • Pelvic inflammatory disease: infection of the reproductive organs.
  • Uterine perforation: rare injury to the uterine wall during insertion.
  • Ectopic pregnancy: pregnancy occurring outside the uterus.
  • Expulsion of the device: spontaneous loss of the IUS.
  • Hormone‑dependent tumor growth: rare stimulation of existing neoplasms.

Precautions & Warnings

Before using Mirena, certain precautions and warnings should be considered.

  • Contraindications: avoid if current pregnancy, active pelvic infection, or known uterine anomalies.
  • Screening: perform a pelvic exam and ultrasound to confirm uterine size and position.
  • Follow‑up: schedule a check‑up 4–6 weeks after insertion to verify placement.
  • Medication interactions: certain enzyme‑inducing drugs may reduce levonorgestrel effectiveness.
  • Breastfeeding: discuss risks and benefits with a healthcare provider if lactating.
  • Store at ambient temperature: keep the device in its original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel intrauterine system may interact with other medicines that affect hormone levels or uterine environment.

Major Interactions (Avoid)

  • Enzyme inducers: rifampin, carbamazepine, phenytoin may lower levonorgestrel concentrations.
  • Antifungal azoles: ketoconazole can increase systemic exposure, raising side‑effect risk.

Moderate Interactions (Monitor Closely)

  • Antiepileptics: valproic acid may alter hormone metabolism.
  • Antiretrovirals: efavirenz may reduce efficacy.
  • Herbal supplements: St. John’s wort may decrease hormone levels.

Frequently Asked Questions

Mirena is a levonorgestrel‑releasing intrauterine system indicated for up to five years of contraception, reduction of heavy menstrual bleeding, and relief of pain associated with endometriosis. It provides a long‑acting, reversible option for women seeking hormonal birth control and menstrual management.

Levonorgestrel released from the device binds to progesterone receptors in the uterine lining and cervical canal. This suppresses endometrial growth, thickens cervical mucus to block sperm entry, and may inhibit ovulation in some users, thereby preventing pregnancy and reducing menstrual blood loss.

Mirena is supplied as a pre‑loaded intrauterine system that releases approximately 20 µg of levonorgestrel per day. The exact dosing schedule, including insertion and removal timing, is determined by the prescribing healthcare professional based on individual clinical needs.

Mirena must not be used during an existing pregnancy. If pregnancy occurs, the device should be removed. For breastfeeding women, the benefits and risks should be discussed with a healthcare provider, as levonorgestrel is excreted in small amounts in breast milk.

To order Mirena, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative is the copper intrauterine device, which provides non‑hormonal contraception. Mirena offers hormonal action that reduces menstrual bleeding and can relieve endometriosis‑related pain, whereas copper IUDs may increase menstrual flow. Choice depends on patient preference, medical history and desired side‑effect profile.

Mirena should be stored at ambient temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and extreme temperatures to maintain the integrity of the hormone‑release mechanism until insertion.

Mirena is inserted into the uterine cavity by a trained healthcare professional using a specialized inserter. The procedure is performed in a clinical setting after a pelvic examination and, if needed, cervical preparation. Once placed, the device remains effective for up to five years.

Serious risks include uterine perforation during insertion, pelvic inflammatory disease, ectopic pregnancy if contraception fails, and rare cases of device expulsion. Women should seek immediate medical attention for severe abdominal pain, abnormal bleeding, fever or signs of infection.

Mirena is contraindicated in women who are currently pregnant, have active pelvic infections, unexplained vaginal bleeding, known or suspected uterine malignancy, severe liver disease, or uterine anomalies that prevent proper placement. A thorough medical evaluation is required before insertion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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