Product image of Mirena (Levonorgestrel) supplied by GNH India

Mirena

Active Ingredient:
Levonorgestrel
Origin:
EU

Mirena (Levonorgestrel)

Levonorgestrel, the active ingredient in Mirena, is a progestogen presented as a 52 mg intrauterine system for intrauterine use. It provides long‑acting contraception for up to five years and is also indicated for the management of heavy menstrual bleeding in women of reproductive age.

GNH India supplies Mirena as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU regulatory standards and is distributed under strict quality controls.

Manufacturer / TM Owner

Bayer Sa Nv

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Indications & Clinical Uses

Mirena, a levonorgestrel‑releasing intrauterine system, is used in hormonal contraceptive and menstrual‑management pathways.

  • Contraception: provides up to five years of highly effective birth control for women of reproductive age.
  • Heavy menstrual bleeding: reduces menstrual blood loss and may improve anemia.
  • Endometrial protection: maintains a thin endometrium, lowering the risk of hyperplasia.

How It Works

  • Levonorgestrel released locally from the intrauterine system acts on cervical mucus, the endometrium and, in some cycles, the ovary. It thickens cervical mucus to impede sperm penetration, suppresses endometrial proliferation resulting in a thin lining, and may inhibit ovulation, thereby preventing pregnancy and reducing menstrual bleeding while maintaining low systemic hormone levels.

Side Effects

Adverse reactions reported with Mirena can be grouped as common and serious or rare.

Common Side Effects

  • Irregular bleeding or spotting
  • Amenorrhea (absence of periods)
  • Headache
  • Breast tenderness

Serious or Rare Side Effects

  • Pelvic inflammatory disease
  • Uterine perforation during insertion
  • Device expulsion

Precautions & Warnings

Before insertion and during use, several precautions should be observed.

  • Pregnancy screening: confirm the patient is not pregnant prior to insertion.
  • Infection risk: treat any active pelvic infection before placement.
  • Uterine anomalies: assess for fibroids, septa or other malformations.
  • Follow‑up visits: schedule regular checks to verify device position.
  • Contraindications: avoid in women with known or suspected reproductive‑organ malignancy.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel may interact with other medicines, requiring attention to certain combinations.

Major Interactions (Avoid)

  • Enzyme inducers such as rifampicin may reduce contraceptive efficacy.
  • Antifungal azoles (e.g., ketoconazole) can increase systemic levonorgestrel levels.
  • Protease inhibitors (e.g., ritonavir) may alter hormone metabolism.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants like phenytoin or carbamazepine may lower effectiveness.
  • St. John’s wort may diminish contraceptive protection.
  • Concurrent hormonal therapies may increase risk of hormonal side effects.

Frequently Asked Questions

Mirena is a levonorgestrel‑releasing intrauterine system indicated for long‑acting contraception up to five years and for the management of heavy menstrual bleeding in women of reproductive age.

Levonorgestrel released from the intrauterine system thickens cervical mucus, suppresses endometrial growth, and may inhibit ovulation, creating a hostile environment for sperm and reducing menstrual blood loss.

The intrauterine system contains 52 mg of levonorgestrel and provides continuous release for up to five years; the exact dosing regimen is determined by the prescribing clinician at the time of insertion.

Mirena is contraindicated in pregnancy (Category X) and should be removed if pregnancy occurs. It is generally not recommended for use while breastfeeding during the first six weeks postpartum; clinicians should assess risks and benefits.

To place an order, submit an enquiry on the Mirena product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Compared with oral hormonal contraceptives, Mirena offers a once‑in‑a‑lifetime insertion providing up to five years of protection, higher typical‑use efficacy, and reduced systemic hormone exposure. Unlike copper IUDs, it delivers progestogen, which can lessen menstrual bleeding.

Mirena should be stored at ambient temperature, below 25 °C, in its original sealed packaging, protected from moisture and direct sunlight to maintain device integrity until insertion.

Mirena is inserted by a trained healthcare professional through the cervical canal into the uterine cavity using a specialized inserter. The procedure is performed in a clinical setting under aseptic conditions.

Serious risks include pelvic inflammatory disease, uterine perforation during insertion, and device expulsion, which can lead to unintended pregnancy. Prompt medical evaluation is required if symptoms such as severe abdominal pain, abnormal bleeding or signs of infection occur.

Women with current pregnancy, active pelvic infection, known or suspected uterine or breast cancer, unexplained vaginal bleeding, or uterine anomalies such as large fibroids should not use Mirena. Contraindications are outlined in the product labeling.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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