Product image of Mirena (Levonorgestrel) supplied by GNH India

Mirena

Active Ingredient:
Levonorgestrel
Origin:
EU

Mirena (Levonorgestrel)

Levonorgestrel, the active ingredient in Mirena, is a progestin presented as a 52 mg (20 µg/day release) intrauterine system for intrauterine use. It prevents pregnancy, reduces menstrual bleeding, and is also employed to manage heavy menstrual bleeding and endometriosis‑associated pain.

GNH India supplies Mirena as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Plc

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Indications & Clinical Uses

Mirena (levonorgestrel) is a hormonal contraceptive that acts on the uterine environment to provide long‑term birth control and manage menstrual disorders.

  • Contraception: provides up to five years of highly effective pregnancy prevention.
  • Heavy menstrual bleeding: reduces menstrual blood loss and improves quality of life.
  • Endometriosis‑associated pain: alleviates pelvic pain related to endometriosis.

How It Works

  • Levonorgestrel released from the intrauterine system acts locally on the endometrium and cervical mucus. It suppresses endometrial proliferation, thickens cervical mucus to impede sperm penetration, and may inhibit ovulation in some users, thereby preventing implantation and reducing menstrual bleeding.

Side Effects

Adverse reactions to Mirena are generally related to local uterine effects and systemic hormonal exposure.

Common Side Effects

  • Irregular bleeding: spotting or unpredictable menstrual patterns.
  • Amenorrhea: absence of menstrual bleeding.
  • Pelvic pain: cramping or discomfort in the lower abdomen.

Serious or Rare Side Effects

  • Uterine perforation: rare injury to the uterine wall during insertion.
  • Ectopic pregnancy: pregnancy occurring outside the uterus if contraception fails.
  • Hormone‑dependent tumor growth: potential stimulation of existing estrogen‑sensitive tumors.

Precautions & Warnings

Before using Mirena, clinicians should consider several safety measures.

  • Screening: confirm no current pregnancy and assess uterine anatomy before insertion.
  • Contraindications: avoid in women with active pelvic infection, unexplained vaginal bleeding, or known hypersensitivity to levonorgestrel.
  • Follow‑up: schedule a check‑up 4–6 weeks after insertion to verify placement.
  • Removal: ensure timely removal or replacement at five years to maintain efficacy.
  • Store at ambient temperature: keep the device in its original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levonorgestrel may interact with other medicines that affect hormone metabolism.

Major Interactions (Avoid)

  • Antiepileptic enzyme inducers: strong inducers such as carbamazepine may reduce levonorgestrel effectiveness.
  • Rifampicin: may decrease hormone levels leading to reduced contraceptive efficacy.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles: ketoconazole can increase levonorgestrel concentrations.
  • Antiretrovirals: protease inhibitors may alter hormone metabolism.
  • Herbal supplements: St. John’s wort may lower efficacy.

Frequently Asked Questions

Mirena is an intrauterine system that releases levonorgestrel to provide up to five years of highly effective contraception, reduce heavy menstrual bleeding, and relieve pain associated with endometriosis.

Levonorgestrel acts locally on the uterus by suppressing endometrial growth, thickening cervical mucus to block sperm entry, and in some users inhibiting ovulation, together preventing pregnancy and decreasing menstrual blood loss.

Mirena is supplied as a device that releases approximately 20 µg of levonorgestrel per day for up to five years. The exact dosing schedule is determined by the prescribing clinician at the time of insertion.

Mirena is classified as pregnancy category X and must not be used in women who are pregnant or planning pregnancy. While limited data exist for breastfeeding, clinicians usually assess risks and benefits before recommending use.

To order Mirena, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with smaller‑dose IUDs such as Kyleena, Mirena delivers a higher daily levonorgestrel release (20 µg vs. 17.5 µg) and is approved for a broader range of indications, including treatment of heavy menstrual bleeding and endometriosis‑related pain.

Mirena should be stored at ambient temperature, below 25 °C, in its original sealed packaging. Protect the device from moisture, direct sunlight and physical damage until it is inserted by a qualified healthcare professional.

Mirena is inserted into the uterine cavity by a trained clinician using a specialized inserter. The procedure is performed in a clinical setting under aseptic conditions, and placement is confirmed by a pelvic exam or ultrasound.

Serious risks include uterine perforation during insertion, ectopic pregnancy if contraception fails, and the rare possibility of hormone‑dependent tumor growth. Patients should seek immediate medical attention for severe abdominal pain, abnormal bleeding or signs of infection.

Mirena is contraindicated in women who are currently pregnant, have active pelvic infections, unexplained vaginal bleeding, known or suspected uterine anomalies, or a hypersensitivity to levonorgestrel or any component of the device.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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