Product image of Mirta Tad (Mirtazapine) supplied by GNH India

Mirta Tad

Active Ingredient:
Mirtazapine
Origin:
EU

Mirta Tad (Mirtazapine)

Mirtazapine, the active ingredient in Mirta Tad, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral tablet for oral use. It is indicated for the treatment of major depressive disorder in adult patients.
GNH India supplies Mirta Tad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tad Pharma Gmbh

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Indications & Clinical Uses

Mirtazapine is a NaSSA antidepressant used to address depressive disorders.

  • Major depressive disorder: reduces depressive symptoms and improves mood in adults.
  • Depression with insomnia: helps alleviate sleep disturbances associated with depression.
  • Depression with anxiety: may improve anxiety symptoms that coexist with depressive episodes.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks 5‑HT2 and 5‑HT3 receptors while stimulating 5‑HT1A receptors, thereby enhancing serotonergic and noradrenergic neurotransmission that contributes to its antidepressant effect.

Side Effects

Mirtazapine may cause a range of adverse reactions.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Peripheral edema

Serious or Rare Side Effects

  • Agranulocytosis or neutropenia
  • Severe hypersensitivity reactions
  • Serotonin syndrome when combined with other serotonergic agents
  • Suicidal thoughts or worsening depression
  • Hepatic dysfunction
  • Seizures (rare)

Precautions & Warnings

When prescribing or dispensing Mirta Tad, consider the following precautions.

  • Hepatic function assessment: evaluate liver status before initiation.
  • Mood monitoring: watch for worsening depression or emergent suicidal ideation.
  • Elderly patients: use caution due to increased risk of sedation and falls.
  • Discontinuation: avoid abrupt cessation to reduce withdrawal phenomena.
  • Concomitant CNS depressants: monitor for additive sedation.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mirtazapine can interact with several drug classes.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of severe serotonin syndrome.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol): heightened serotonin toxicity.
  • Alcohol or potent CNS depressants: excessive sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase mirtazapine plasma levels.
  • Antihypertensives: additive hypotensive effect.
  • Carbamazepine: may reduce mirtazapine concentrations, diminishing efficacy.

Frequently Asked Questions

Mirta Tad contains mirtazapine, a NaSSA antidepressant that is prescribed primarily for the management of major depressive disorder in adult patients. It helps alleviate depressive symptoms such as low mood, loss of interest, and associated sleep disturbances.

Mirtazapine blocks presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and antagonizes 5‑HT2 and 5‑HT3 receptors while stimulating 5‑HT1A receptors. This combined action enhances serotonergic and noradrenergic neurotransmission, contributing to its antidepressant effect.

The appropriate dose of Mirta Tad is determined by the prescribing clinician based on the individual’s clinical condition, response, and tolerability. Dosage adjustments are made according to professional guidelines and patient-specific factors.

Safety data for mirtazapine in pregnancy and lactation are limited. The prescriber should weigh potential benefits against possible risks and consider alternative therapies when appropriate. Women who are pregnant or nursing should discuss treatment options with their healthcare provider.

To request Mirta Tad, submit an enquiry on the product page at gnhindia.com, specifying the desired quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any required import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), mirtazapine has a distinct receptor profile that often results in greater sedation and appetite stimulation, which can be advantageous for patients with insomnia or weight loss. However, its side‑effect profile differs, and choice of therapy should be individualized.

Mirta Tad should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight, and excessive heat to maintain product stability.

Mirta Tad is taken orally, usually once daily in the evening with or without food, as directed by the prescriber. Swallow the tablet whole; do not crush or chew unless specifically instructed.

Serious risks include the potential for agranulocytosis, severe hypersensitivity reactions, serotonin syndrome when combined with other serotonergic drugs, and worsening depression or emergence of suicidal thoughts. Immediate medical attention is required if any of these occur.

Mirta Tad is contraindicated in patients with known hypersensitivity to mirtazapine or any of its excipients, and it should be avoided in individuals currently taking monoamine oxidase inhibitors (MAOIs) or those with a history of severe serotonin syndrome. Caution is also advised for patients with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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