Mirtadepi (Mirtazapine)

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases the release of norepinephrine. It also antagonizes postsynaptic 5‑HT2, 5‑HT3 and histamine H1 receptors, leading to enhanced serotonergic transmission and sedation. These combined actions help alleviate depressive mood, anxiety, and sleep disturbances.

The appropriate dose of Mirtadepi is determined by the prescribing clinician based on the individual patient's condition, response, and tolerability. Dosage may be started at a low level and adjusted as needed, but specific dosing regimens should only be provided by a qualified healthcare professional.

The safety of mirtazapine in pregnancy and lactation has not been definitively established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should discuss individual risks and consider alternative therapies when appropriate.

To request Mirtadepi, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Mirtadepi (mirtazapine) belongs to the NaSSA class, which differs from SSRIs and SNRIs by its dual antagonism of α2‑adrenergic and certain serotonin receptors. This profile often results in stronger sedative and appetite‑stimulating effects, making it useful for patients with insomnia or weight loss, whereas other antidepressants may have less pronounced sedation.

Mirtadepi should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, excessive heat and direct sunlight. Do not store in a refrigerator or freezer, and keep out of reach of children.

Mirtadepi is taken orally, usually once daily in the evening due to its sedative properties. The tablet should be swallowed whole with water and not chewed or crushed unless otherwise directed by a healthcare professional.

Serious adverse events include agranulocytosis, severe neutropenia, Stevens‑Johnson syndrome, and worsening depression with possible suicidal thoughts. Patients should be monitored for signs of infection, skin reactions, sudden mood changes, or unexplained dizziness, and seek immediate medical attention if these occur.

Mirtadepi is contraindicated in patients who have a known hypersensitivity to mirtazapine or any of its excipients. It should also be avoided in individuals currently taking monoamine oxidase inhibitors (MAOIs) or those with severe hepatic impairment without appropriate medical supervision.