Mirtazapin Actavis (Mirtazapine)

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases the release of norepinephrine, and by antagonizing postsynaptic 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic activity. Its additional antagonism of histamine H1 receptors contributes to its sedative effect, together restoring neurotransmitter balance implicated in depression.

The appropriate dose of Mirtazapin Actavis is determined individually by the prescribing clinician based on the patient’s clinical condition, response, and tolerability. Dosage may be adjusted over time, and patients should follow the specific instructions provided by their healthcare provider.

Safety data for mirtazapine in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss risks and alternatives with their healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After receiving the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and assist with import documentation.

Mirtazapine belongs to the NaSSA class, whereas many other antidepressants, such as SSRIs and SNRIs, primarily increase serotonin or both serotonin and norepinephrine levels. Mirtazapine’s strong antihistamine effect often leads to sedation and weight gain, which can be advantageous for patients with insomnia or appetite loss, but may be less desirable for those concerned about metabolic side effects.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light, and ensure the container is tightly closed. Do not store in the bathroom or near heat sources, and keep out of reach of children.

Mirtazapin Actavis is taken orally, usually once daily in the evening. Tablets should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise directed by a healthcare professional. Food does not significantly affect absorption, so it can be taken with or without meals.

Serious risks include agranulocytosis or severe neutropenia, which can lead to infection, and rare dermatologic reactions such as Stevens‑Johnson syndrome. Additionally, mirtazapine may increase suicidal thoughts or behaviors, particularly during the initial treatment period or when doses are changed. Patients should be monitored closely for any signs of infection, severe skin reactions, or worsening mood.

Mirtazapin Actavis should be avoided in individuals with known hypersensitivity to mirtazapine or any of its excipients. It is also contraindicated in patients who have taken a monoamine oxidase inhibitor within the past 14 days, and caution is advised for those with severe hepatic impairment or a history of blood dyscrasias.