Product image of Mirtazapin Aurobindo (Mirtazapine) supplied by GNH India

Mirtazapin Aurobindo

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapin Aurobindo (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapin Aurobindo, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral dosage form for oral use. It is indicated for the treatment of major depressive disorder in adult patients.

GNH India supplies Mirtazapin Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma (Malta) Limited

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Indications & Clinical Uses

Mirtazapine, marketed as Mirtazapin Aurobindo, is used in the management of depressive disorders.

  • Major depressive disorder: alleviates depressive symptoms and improves mood in affected individuals.

How It Works

  • Mirtazapine exerts its antidepressant effect by antagonising central presynaptic α2‑adrenergic receptors, which enhances the release of norepinephrine and serotonin. It also blocks postsynaptic 5‑HT2 and 5‑HT3 receptors and H1 histamine receptors, contributing to increased serotonergic neurotransmission and sedation. The combined actions result in elevated monoaminergic activity that mitigates depressive symptoms.

Side Effects

Mirtazapin Aurobindo may be associated with a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Sedation: feeling of drowsiness or sleepiness.
  • Increased appetite and weight gain: heightened hunger leading to weight increase.
  • Dry mouth: reduced salivation causing oral dryness.
  • Dizziness: sensation of light‑headedness or unsteadiness.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells requiring immediate medical attention.
  • Seizures: occurrence of convulsive episodes, especially in predisposed individuals.
  • Suicidal thoughts or behavior: emergence of new or worsening suicidal ideation.

Precautions & Warnings

When prescribing Mirtazapin Aurobindo, several safety considerations should be observed.

  • Pregnancy: Category B – use only if potential benefit justifies the potential risk to the fetus.
  • Elderly patients: monitor for excessive sedation and increased fall risk.
  • Renal impairment: consider dose adjustment and monitor renal function.
  • Concomitant CNS depressants: may potentiate sedation and respiratory depression.
  • Suicidal ideation: closely observe patients during treatment initiation and dose changes.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and light.

Avoid Interactions

Mirtazapin Aurobindo can interact with other medicines; awareness of the interaction level helps guide clinical decisions.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): concurrent use can cause hypertensive crisis or serotonin syndrome.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol): increased risk of serotonin syndrome.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may raise mirtazapine plasma concentrations.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., carbamazepine, phenytoin): may reduce therapeutic effectiveness.
  • Alcohol: additive central nervous system depression leading to enhanced sedation.

Frequently Asked Questions

Mirtazapin Aurobindo contains the antidepressant mirtazapine and is prescribed for the treatment of major depressive disorder. It helps relieve depressive symptoms such as low mood, loss of interest, and impaired concentration in adult patients.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases the release of norepinephrine and serotonin. It also antagonises postsynaptic 5‑HT2, 5‑HT3 and H1 receptors, enhancing serotonergic activity while producing sedative effects that contribute to its antidepressant action.

The appropriate dose of Mirtazapin Aurobindo is determined by the prescribing clinician based on the patient’s clinical condition, response, and tolerability. Dosage adjustments may be required for special populations, and patients should follow the prescriber’s instructions exactly.

Mirtazapin Aurobindo is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are no adequate human studies. It should be used only if the potential benefit justifies any possible risk to the fetus, and breastfeeding decisions should be made in consultation with a healthcare professional.

To order Mirtazapin Aurobindo, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), mirtazapine has a distinct receptor profile that often results in stronger sedative and appetite‑stimulating effects. It may be preferred when patients experience insomnia or weight loss, but the choice of therapy should be individualized based on efficacy, side‑effect tolerance and comorbid conditions.

Mirtazapin Aurobindo should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Mirtazapin Aurobindo is taken orally, usually once daily in the evening to take advantage of its sedative properties. The tablet should be swallowed whole with water and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include agranulocytosis, seizures, and the emergence or worsening of suicidal thoughts, especially during the early phase of treatment. Patients should be monitored closely for signs of infection, convulsions, or any change in mood or behavior, and seek immediate medical attention if these occur.

Mirtazapin Aurobindo should be avoided in patients with known hypersensitivity to mirtazapine or any of its excipients, and in individuals currently taking monoamine oxidase inhibitors (MAOIs) unless a wash‑out period of at least 14 days has been observed. Caution is also advised for patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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