Product image of Mirtazapin !@ctavis (Mirtazapine) supplied by GNH India

Mirtazapin !@ctavis

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapin !@ctavis (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapin !@ctavis, is a NaSSA presented as an oral dosage form for oral use. It is indicated for the treatment of major depressive disorder in adult patients.

GNH India supplies Mirtazapin !@ctavis as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

Mirtazapine is used within the antidepressant therapeutic class to manage depressive conditions.

  • Major depressive disorder: reduces depressive symptoms and improves mood in adults.
  • Depressive episodes in major depressive disorder: helps restore sleep and appetite.
  • Treatment‑resistant major depressive disorder: may be considered when other antidepressants have not achieved adequate response.

How It Works

  • Mirtazapine acts as an antagonist at central presynaptic α2‑adrenergic receptors, enhancing norepinephrine release, and blocks serotonin 5‑HT2 and 5‑HT3 receptors, which increases serotonergic neurotransmission while reducing associated side‑effects. This combined activity contributes to its antidepressant effect.

Side Effects

Mirtazapine may cause a range of adverse reactions.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite leading to weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Orthostatic hypotension

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Severe hypersensitivity reactions (e.g., Stevens‑Johnson syndrome)
  • Suicidal thoughts or behavior, especially early in treatment
  • Serotonin syndrome when combined with other serotonergic agents

Precautions & Warnings

Mirtazapine requires careful monitoring in several clinical situations.

  • Assess hepatic function: adjust use in severe liver impairment.
  • Monitor weight: potential for significant weight gain.
  • Evaluate for suicidal ideation: particularly during the initial treatment phase.
  • Avoid abrupt discontinuation: taper dosage to reduce withdrawal symptoms.
  • Use caution in elderly patients: increased risk of sedation and falls.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Mirtazapine can interact with a variety of medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors: risk of hypertensive crisis.
  • Other serotonergic agents (e.g., SSRIs, SNRIs): potential serotonin syndrome.
  • Strong CYP2D6 inhibitors: may raise mirtazapine plasma levels.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines, alcohol): additive sedation.
  • Antihistamines: increased drowsiness.
  • Carbamazepine or other enzyme inducers: may reduce efficacy of mirtazapine.

Frequently Asked Questions

Mirtazapin !@ctavis contains mirtazapine, an antidepressant that is prescribed to treat major depressive disorder in adult patients. It helps alleviate depressive symptoms such as low mood, loss of interest, and sleep disturbances.

Mirtazapine blocks presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and antagonizes serotonin 5‑HT2 and 5‑HT3 receptors. This dual action enhances overall serotonergic and noradrenergic neurotransmission, contributing to its antidepressant effect.

The appropriate dose of Mirtazapin !@ctavis is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and tolerability. Patients should follow the dosage instructions provided by their healthcare professional.

The safety of mirtazapine in pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and consider alternative treatments when appropriate.

To request Mirtazapin !@ctavis, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from SSRIs and SNRIs by its receptor profile. It often causes sedation and weight gain, which can be advantageous for patients with insomnia or low appetite, whereas SSRIs may have a lower risk of these effects but can cause sexual dysfunction.

Mirtazapin !@ctavis should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Mirtazapin !@ctavis is taken orally, usually once daily in the evening, as directed by a healthcare professional. It can be swallowed whole with water; tablets should not be crushed or chewed unless specifically instructed.

Serious risks include the potential for agranulocytosis, severe hypersensitivity reactions, and the emergence or worsening of suicidal thoughts, especially during the early weeks of therapy. Patients should be monitored closely for any signs of these conditions.

Mirtazapin !@ctavis is contraindicated in patients who have taken monoamine oxidase inhibitors within the past 14 days, those with known hypersensitivity to mirtazapine, and individuals with severe hepatic impairment without appropriate dose adjustment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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