Product image of Mirtazapin Neuraxpharm (Mirtazapine) supplied by GNH India

Mirtazapin Neuraxpharm

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapin Neuraxpharm (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapin Neuraxpharm, is a Noradrenergic and specific serotonergic antidepressant (NaSSA) presented as an oral tablet for oral use. It is indicated for the treatment of major depressive disorder in adult patients and works by modulating norepinephrine and serotonin pathways to improve mood, sleep and appetite.

GNH India supplies Mirtazapin Neuraxpharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Neuraxpharm Arzneimittel Gmbh

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Indications & Clinical Uses

Mirtazapine is a NaSSA antidepressant used primarily in the management of depressive disorders.

  • Major depressive disorder: reduces depressive symptoms and improves overall functioning.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks 5‑HT2 and 5‑HT3 receptors while strongly inhibiting H1 receptors. This combined action enhances serotonergic and noradrenergic neurotransmission, leading to mood elevation and anxiolytic effects.

Side Effects

Mirtazapine may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Fatigue

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Suicidal ideation or behavior
  • Severe hypotension
  • Hepatic dysfunction or failure

Precautions & Warnings

When prescribing Mirtazapine, clinicians should consider several safety precautions.

  • Pregnancy: use only if potential benefit justifies the potential risk to the fetus.
  • Breastfeeding: safety not established; consider alternative therapy.
  • Elderly: monitor for excessive sedation and increased fall risk.
  • Concomitant CNS depressants: may enhance sedative effects.
  • History of bipolar disorder: risk of mood switching to mania.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Mirtazapine can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis; avoid co‑administration.
  • Carbamazepine: strong enzyme inducer that reduces mirtazapine plasma levels.
  • Fluoxetine: CYP2D6 inhibition may increase mirtazapine concentrations.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive central nervous system depression.
  • Other serotonergic agents (e.g., tramadol, linezolid): potential serotonin syndrome.
  • Warfarin: may alter INR; monitor coagulation parameters.

Frequently Asked Questions

Mirtazapin Neuraxpharm contains mirtazapine, which is prescribed to treat major depressive disorder in adult patients. It helps alleviate depressive symptoms such as low mood, loss of interest, and sleep disturbances by enhancing norepinephrine and serotonin activity in the brain.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases the release of norepinephrine. It also antagonizes certain serotonin receptors (5‑HT2 and 5‑HT3) and strongly blocks H1 histamine receptors, resulting in enhanced serotonergic and noradrenergic neurotransmission and a calming, mood‑lifting effect.

The appropriate dose of Mirtazapin Neuraxpharm is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and tolerability. Dosage adjustments are made according to clinical judgment and patient needs.

Safety data for mirtazapine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers usually consider alternative treatments for pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from selective serotonin reuptake inhibitors (SSRIs) and serotonin‑norepinephrine reuptake inhibitors (SNRIs). It often causes more sedation and weight gain but may be preferred when patients experience insomnia or poor appetite, whereas SSRIs are generally more activating.

Mirtazapin Neuraxpharm should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and store them out of reach of children.

The medication is taken orally, usually once daily in the evening due to its sedative effect. It should be swallowed whole with water and not chewed or crushed unless otherwise directed by a healthcare professional.

Serious risks include the potential for agranulocytosis, severe skin reactions such as Stevens‑Johnson syndrome, significant weight gain, and the emergence or worsening of suicidal thoughts, especially during the initial treatment period. Patients should be monitored closely for any of these events.

Mirtazapin Neuraxpharm is contraindicated in patients who have taken monoamine oxidase inhibitors within the past 14 days, those with known hypersensitivity to mirtazapine, and individuals with severe hepatic impairment. Caution is also advised for patients with a history of bipolar disorder or uncontrolled hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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