Product image of Mirtazapin Teva (Mirtazapine) supplied by GNH India

Mirtazapin Teva

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapin Teva (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapin Teva, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral dosage form for oral use. It is indicated for the treatment of major depressive disorder in adult patients. The medication works by modulating neurotransmitter activity, thereby improving mood and alleviating depressive symptoms.

GNH India supplies Mirtazapin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and research institutions worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Mirtazapine is used primarily in the management of depressive disorders.

  • Major depressive disorder (single episode): reduces depressive symptoms and improves functional status.
  • Major depressive disorder (recurrent): helps maintain remission and prevent relapse.
  • Depressive symptoms with anxiety comorbidity: may improve both mood and anxiety levels.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic transmission while sparing 5‑HT1A. This combined action raises synaptic concentrations of norepinephrine and serotonin, contributing to its antidepressant effect.

Side Effects

Mirtazapine may cause a range of adverse reactions, which are generally categorized by frequency.

Common Side Effects

  • Sedation or drowsiness.
  • Increased appetite and weight gain.
  • Dry mouth.
  • Constipation.
  • Dizziness.
  • Orthostatic hypotension.

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Suicidal thoughts or worsening depression.
  • Severe hypotension or syncope.
  • Seizures.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor for worsening depression or emergence of suicidal thoughts: assess patients regularly, especially during early treatment.
  • Use with caution in patients with hepatic impairment: dose adjustment may be required.
  • Avoid abrupt discontinuation: taper under medical supervision to reduce withdrawal risk.
  • Exercise caution in elderly patients: increased sedation may raise fall risk.
  • Assess for hypersensitivity reactions: discontinue if rash or angioedema occurs.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Mirtazapine can interact with several drug classes, necessitating careful review of a patient’s medication list.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol): may precipitate serotonin syndrome.
  • Central nervous system depressants (e.g., benzodiazepines, alcohol): additive sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase mirtazapine plasma levels.
  • CYP3A4 inducers (e.g., carbamazepine, rifampicin): may reduce efficacy.
  • Anticoagulants (e.g., warfarin): monitor INR for potential changes.

Frequently Asked Questions

Mirtazapin Teva contains mirtazapine, which is prescribed for the treatment of major depressive disorder in adult patients. It helps alleviate depressive symptoms, improve mood, and restore functional capacity when used as part of a comprehensive treatment plan.

Mirtazapine blocks presynaptic α2‑adrenergic receptors, leading to increased release of norepinephrine, and antagonizes 5‑HT2 and 5‑HT3 receptors while sparing 5‑HT1A. This dual action raises serotonin and norepinephrine levels in the brain, producing an antidepressant effect.

The appropriate dose of Mirtazapin Teva is determined by the prescribing clinician based on the patient’s clinical condition, response to therapy, and tolerability. Dosage adjustments are made individually; patients should follow the prescriber’s instructions and not alter the dose on their own.

Safety data for mirtazapine during pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers will evaluate each case and discuss alternatives when appropriate.

To request Mirtazapin Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapin Teva (mirtazapine) belongs to the NaSSA class, differing from SSRIs and SNRIs by its combined noradrenergic and specific serotonergic activity and strong antihistamine effect. This profile often results in greater sedation and appetite stimulation, which can be advantageous for patients with insomnia or weight loss, but may be less suitable for those who need a more activating agent.

Store Mirtazapin Teva at room temperature, below 25 °C, in the original container. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations. Keep it out of reach of children and do not use if the packaging is damaged.

Mirtazapin Teva is taken orally, usually once daily in the evening because of its sedative effect. It can be swallowed whole with water and may be taken with or without food, unless the prescriber advises otherwise.

Serious risks include the potential for agranulocytosis or severe neutropenia, life‑threatening skin reactions such as Stevens‑Johnson syndrome, worsening depression or emergence of suicidal thoughts, severe hypotension, and rare seizures. Patients should be monitored closely for any of these events.

Mirtazapin Teva should be avoided in patients who are currently taking monoamine oxidase inhibitors (MAOIs) or have taken an MAOI within the past 14 days, those with known hypersensitivity to mirtazapine, and individuals with severe hepatic impairment unless dose adjustments are made under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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