Product image of Mirtazapin Teva B.V (Mirtazapine) supplied by GNH India

Mirtazapin Teva B.V

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapin Teva B.V (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapin Teva B.V, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral formulation for oral use. It is indicated for the treatment of major depressive disorder in adult patients and works by modulating neurotransmitter activity to improve mood.

GNH India supplies Mirtazapin Teva B.V as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide under stringent quality assurance protocols.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Mirtazapine is used primarily in the management of depressive disorders.

  • Major depressive disorder: reduces depressive symptoms and improves functional outcomes.
  • Depressive symptoms with comorbid anxiety: may alleviate mood disturbances and anxiety features.
  • Treatment‑resistant depression (adjunct therapy): can be added when first‑line agents are insufficient.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and blocks postsynaptic 5‑HT2 and 5‑HT3 receptors while also inhibiting H1 histamine receptors. This combined action enhances noradrenergic and serotonergic neurotransmission and produces sedative and appetite‑stimulating effects that contribute to its antidepressant activity.

Side Effects

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Peripheral edema

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Seizures
  • Suicidal thoughts or behavior
  • Severe hypersensitivity reactions (e.g., Stevens‑Johnson syndrome)
  • Hepatic dysfunction
  • Orthostatic hypotension

Precautions & Warnings

Mirtazapine should be prescribed after a thorough psychiatric assessment and with ongoing monitoring.

  • Suicidality: monitor for emergence or worsening of suicidal thoughts, especially early in treatment.
  • Hepatic impairment: use with caution and consider dose adjustment in patients with liver disease.
  • Abrupt discontinuation: taper gradually to avoid withdrawal symptoms.
  • Elderly patients: start at low dose and monitor for excessive sedation or falls.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mirtazapine may interact with several other medicines, requiring careful management.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome.
  • CNS depressants (e.g., benzodiazepines, opioids): additive sedation.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase mirtazapine levels.

Moderate Interactions (Monitor Closely)

  • Other serotonergic agents (e.g., SSRIs, SNRIs): monitor for serotonin syndrome.
  • Antihistamines: may enhance sedative effect.
  • Alcohol: can increase central nervous system depression.
  • Carbamazepine: may reduce mirtazapine exposure.

Frequently Asked Questions

Mirtazapin Teva B.V contains the active ingredient mirtazapine, which is prescribed to treat major depressive disorder in adult patients. It helps alleviate depressive symptoms and improve overall mood and functioning.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, leading to increased release of norepinephrine, and by antagonising postsynaptic 5‑HT2, 5‑HT3 and H1 receptors. This dual action enhances serotonergic and noradrenergic neurotransmission while providing sedative and appetite‑stimulating effects.

The appropriate dose of mirtazapine is determined individually by the prescribing clinician based on the patient’s clinical condition, response to therapy, and tolerability. Dosage adjustments are made according to professional guidelines and patient needs.

Mirtazapine is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but insufficient human data. It should be used during pregnancy only if the potential benefit justifies the risk. Breastfeeding is not recommended unless the benefit outweighs potential infant exposure.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from SSRIs and SNRIs by its combined noradrenergic and serotonergic activity and strong antihistamine effect. This profile often results in pronounced sedation and weight gain, which can be advantageous for patients with insomnia or loss of appetite, but may be less suitable for those concerned about these side effects.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Mirtazapin Teva B.V is taken orally, usually once daily in the evening due to its sedative properties. The tablet should be swallowed whole with water and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious risks include the potential for agranulocytosis or severe neutropenia, seizures, hepatic dysfunction, and rare but severe hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should be monitored for signs of infection, liver abnormalities, or allergic reactions, and the drug should be discontinued if these occur.

Mirtazapin Teva B.V should be avoided in patients with known hypersensitivity to mirtazapine or any of its excipients, those currently taking monoamine oxidase inhibitors, and individuals with severe hepatic impairment unless the prescriber determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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