Product image of Mirtazapina Aurobindo (Mirtazapine) supplied by GNH India

Mirtazapina Aurobindo

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapina Aurobindo (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapina Aurobindo, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral tablet for oral use. It treats major depressive disorder in adult patients.
GNH India supplies Mirtazapina Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Generis Farmacêutica, S.A.

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Indications & Clinical Uses

  • Mirtazapine is indicated for depressive disorders and works by modulating noradrenergic and serotonergic pathways.
  • Major depressive disorder: reduces depressive symptoms and improves mood and sleep quality.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic neurotransmission while sparing 5‑HT1 receptors. This combined action leads to antidepressant and anxiolytic effects.

Side Effects

Mirtazapine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Orthostatic hypotension

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Suicidal thoughts or behavior
  • Seizures
  • Hyponatremia
  • Severe hepatic dysfunction

Precautions & Warnings

Before prescribing mirtazapine, clinicians should consider several safety aspects.

  • Assess hepatic function: adjust dose if liver impairment is present.
  • Monitor for suicidal ideation: especially during early treatment.
  • Use caution in elderly: higher risk of sedation and falls.
  • Avoid abrupt discontinuation: taper to reduce withdrawal symptoms.
  • Adjust dose in renal impairment: consider reduced clearance.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Mirtazapine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine): may increase mirtazapine plasma levels.
  • Other serotonergic agents (e.g., tramadol, triptans): potential serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive central nervous system depression.
  • Antihistamines: increased sedation.
  • CNS depressants (e.g., benzodiazepines): enhanced drowsiness and impaired coordination.

Frequently Asked Questions

Mirtazapina Aurobindo contains the antidepressant mirtazapine and is used to treat major depressive disorder in adult patients. It helps improve mood, sleep, and overall functioning by acting on specific brain neurotransmitter pathways.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by antagonizing 5‑HT2 and 5‑HT3 serotonin receptors. This dual action enhances serotonergic and noradrenergic transmission, producing antidepressant and anxiolytic effects.

The appropriate dose of Mirtazapina Aurobindo is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage may be adjusted over time, and patients should follow the prescriber’s instructions without self‑adjusting.

Safety data for mirtazapine in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from SSRIs and SNRIs by its combined noradrenergic and specific serotonergic activity. It often causes sedation and weight gain, which can be advantageous for patients with insomnia or low appetite, whereas other antidepressants may have different side‑effect profiles.

Mirtazapina Aurobindo should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, excessive heat, and direct sunlight to maintain stability and potency.

The medication is taken orally, usually once daily in the evening, with or without food. Patients should swallow the tablet whole and follow the dosing schedule prescribed by their healthcare provider.

Serious risks include agranulocytosis, severe neutropenia, Stevens‑Johnson syndrome, hyponatremia, seizures, and the emergence or worsening of suicidal thoughts, especially during the initial treatment period. Prompt medical attention is required if any of these occur.

Mirtazapina Aurobindo should be avoided in patients taking monoamine oxidase inhibitors within the past 14 days, those with known hypersensitivity to mirtazapine, and individuals with severe hepatic impairment unless dose adjustments are made. Consultation with a clinician is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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