Product image of Mirtazapina Aurovitas (Mirtazapine) supplied by GNH India

Mirtazapina Aurovitas

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapina Aurovitas (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapina Aurovitas, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral dosage form for oral use. It is prescribed for the treatment of major depressive disorder in adult patients. It belongs to the class of noradrenergic and specific serotonergic antidepressants and is indicated for patients who require an alternative to selective serotonin reuptake inhibitors.

GNH India supplies Mirtazapina Aurovitas as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Generis Farmacêutica, S.A.

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Indications & Clinical Uses

Mirtazapine is used primarily in the treatment of depressive disorders, acting on noradrenergic and serotonergic pathways.

  • Major depressive disorder: reduction of depressive symptoms in adult patients.
  • Depressive episodes with insomnia: improvement of sleep quality and appetite.
  • Depressive disorder with anxiety: alleviation of anxiety and mood symptoms.

How It Works

  • Mirtazapine acts as an antagonist at central presynaptic α2‑adrenergic receptors, which increases the release of norepinephrine and serotonin. It also blocks postsynaptic 5‑HT2 and 5‑HT3 receptors and antagonizes H1 histamine receptors, enhancing serotonergic transmission while producing sedative effects. The combined actions raise neurotransmitter availability in key brain regions involved in mood regulation. These mechanisms contribute to its antidepressant and anxiolytic profile.

Side Effects

Mirtazapine may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Drowsiness: feeling of sleepiness or fatigue.
  • Increased appetite: heightened hunger leading to weight gain.
  • Dry mouth: reduced salivation causing oral discomfort.
  • Constipation: slowed intestinal transit.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells requiring immediate medical attention.
  • Severe allergic reaction: rash, swelling, or difficulty breathing indicating possible anaphylaxis.
  • Suicidal thoughts: emergence or worsening of suicidal ideation, especially in early treatment.

Precautions & Warnings

Before prescribing mirtazapine, clinicians should consider several safety precautions.

  • Assess psychiatric history: evaluate risk of suicidal ideation, especially in young adults.
  • Monitor weight changes: track body weight and appetite due to potential gain.
  • Review hepatic function: adjust use in patients with liver impairment.
  • Caution with CNS depressants: avoid concurrent use with alcohol or sedatives that may enhance drowsiness.
  • Pregnancy and lactation: consider limited data and weigh benefits against potential risks.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture.

Avoid Interactions

Mirtazapine can interact with other medicines, influencing its effectiveness or safety.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis; avoid concomitant use.
  • Strong CYP3A4 inhibitors: may increase mirtazapine plasma levels, leading to toxicity.
  • CNS depressants: combined sedation and respiratory depression risk.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates: mirtazapine may alter metabolism of drugs like fluoxetine.
  • Anticholinergic agents: additive dry mouth and constipation.
  • Alcohol: enhances sedative effects, requiring caution.

Frequently Asked Questions

Mirtazapina Aurovitas contains mirtazapine, which is prescribed for the treatment of major depressive disorder in adult patients. It helps alleviate depressive symptoms such as low mood, loss of interest, and sleep disturbances.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, increasing norepinephrine and serotonin release. It also antagonizes postsynaptic 5‑HT2, 5‑HT3 and H1 receptors, enhancing serotonergic activity while producing a sedative effect that contributes to its antidepressant action.

The appropriate dose is determined by the prescribing clinician based on the individual’s clinical condition, response, and tolerability. Physicians typically start with a low dose and may adjust it gradually, but exact dosing regimens should not be inferred without a prescription.

Safety data for mirtazapine during pregnancy and lactation are limited. Healthcare providers must weigh potential benefits against possible risks and consider alternative treatments when appropriate. Pregnant or nursing individuals should discuss use with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from selective serotonin reuptake inhibitors (SSRIs) by its dual noradrenergic and serotonergic activity and strong antihistamine effect. This profile often results in greater sedation and appetite stimulation, which can be advantageous for patients with insomnia or weight loss, whereas SSRIs are generally less sedating.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging. Keep it away from moisture and direct sunlight. Do not refrigerate or freeze the tablets, and keep them out of reach of children.

Mirtazapina Aurovitas is taken orally, usually once daily in the evening to take advantage of its sedative properties. The tablet should be swallowed whole with water and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include agranulocytosis, severe allergic reactions such as anaphylaxis, and the emergence or worsening of suicidal thoughts, particularly during the initial weeks of therapy or when doses are changed. Prompt medical attention is required if any of these events occur.

Patients with known hypersensitivity to mirtazapine or any of its excipients should avoid the product. It is also contraindicated in individuals currently taking monoamine oxidase inhibitors (MAOIs) or those with severe hepatic impairment without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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