Product image of Mirtazapina Flas Bluefish (Mirtazapine) supplied by GNH India

Mirtazapina Flas Bluefish

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapina Flas Bluefish (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapina Flas Bluefish, is a NaSSA presented as an oral preparation for oral use. It is prescribed for major depressive disorder in adult patients.

GNH India supplies Mirtazapina Flas Bluefish as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

Mirtazapine is used in the treatment of depressive disorders, acting on serotonergic and noradrenergic pathways.

  • Major depressive disorder: reduces depressive symptoms and improves mood in adults.
  • Depressive disorder with prominent insomnia: helps alleviate sleep disturbances associated with depression.
  • Depression in elderly patients: provides symptom relief while offering a favorable side‑effect profile for older adults.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks postsynaptic 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic transmission while reducing serotonergic side effects. This combined action raises synaptic concentrations of norepinephrine and serotonin, contributing to its antidepressant effect.

Side Effects

Mirtazapine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness

Serious or Rare Side Effects

  • Agranulocytosis
  • Severe neutropenia
  • Hepatotoxicity
  • Seizures
  • Suicidal thoughts or behavior

Precautions & Warnings

When prescribing mirtazapine, clinicians should consider several safety measures.

  • Assess psychiatric history: evaluate risk of suicidal ideation before initiating therapy.
  • Monitor weight and metabolic parameters: watch for significant weight gain or lipid changes.
  • Review hepatic function: adjust use in patients with liver impairment.
  • Caution in elderly: increased sensitivity to sedation and falls.
  • Avoid abrupt discontinuation: taper dose to reduce withdrawal symptoms.
  • Store at ambient temperature: keep below 25 °C in original container, protect from moisture.

Avoid Interactions

Mirtazapine can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome; discontinue MAOI at least 14 days before.
  • Strong CYP1A2 inhibitors (e.g., fluvoxamine): may increase mirtazapine plasma levels.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole): can raise drug concentrations.

Moderate Interactions (Monitor Closely)

  • CNS depressants (benzodiazepines, alcohol): additive sedation.
  • Anticholinergic agents: may exacerbate dry mouth and constipation.
  • Serotonergic agents (SSRIs, SNRIs, tramadol): monitor for serotonin syndrome.

Frequently Asked Questions

Mirtazapina Flas Bluefish contains mirtazapine, an antidepressant indicated for the treatment of major depressive disorder in adult patients. It helps alleviate depressive symptoms such as low mood, loss of interest, and impaired concentration.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases the release of norepinephrine, and by antagonizing postsynaptic 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic activity while reducing certain serotonin‑related side effects.

The appropriate dose of mirtazapine is determined by the prescribing clinician based on the individual’s clinical condition, response, and tolerability. Dosage adjustments are made according to professional guidelines and patient needs.

Safety data for mirtazapine in pregnancy and lactation are limited. Clinicians should weigh potential benefits against possible risks and consider alternative treatments when treating pregnant or nursing individuals.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike SSRIs, which primarily increase serotonin reuptake inhibition, mirtazapine enhances both norepinephrine and serotonin release through its unique receptor profile. It often causes more sedation and weight gain but may be preferred when patients experience insomnia or need a rapid antidepressant effect.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging. Protect it from moisture and direct sunlight to maintain stability and potency throughout its shelf life.

Mirtazapina Flas Bluefish is taken orally, usually once daily in the evening, as directed by the prescribing healthcare professional. Swallow the tablet whole with water; do not crush or split unless specifically instructed.

Serious risks include agranulocytosis, severe neutropenia, hepatotoxicity, seizures, and the emergence or worsening of suicidal thoughts, especially during early treatment or dose changes. Prompt medical attention is required if any of these occur.

Mirtazapine is contraindicated in individuals with known hypersensitivity to the drug, those currently taking monoamine oxidase inhibitors, or patients with severe hepatic impairment where the risk outweighs benefit. Caution is also advised for patients with a history of bipolar disorder or uncontrolled seizures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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