Product image of Mirtazapina Flas Cinfamed (Mirtazapine) supplied by GNH India

Mirtazapina Flas Cinfamed

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapina Flas Cinfamed (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapina Flas Cinfamed, is a noradrenergic and specific serotonergic antidepressant (NaSSA) presented as an oral formulation for systemic use. It is indicated for the treatment of major depressive disorder in adult patients. GNH India supplies Mirtazapina Flas Cinfamed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Cinfa S.A.

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Indications & Clinical Uses

Mirtazapine is used primarily within the depressive disorder therapeutic pathway.

  • Major depressive disorder: alleviates depressive symptoms and improves mood in adults.
  • Treatment‑resistant depression: may be added when first‑line agents are insufficient.
  • Co‑morbid anxiety with depression: can reduce anxiety symptoms alongside depressive improvement.

How It Works

  • Mirtazapine acts as an antagonist at central presynaptic α2‑adrenergic receptors, which enhances norepinephrine release. It also blocks postsynaptic 5‑HT2 and 5‑HT3 receptors and H1 histamine receptors, resulting in increased serotonergic and noradrenergic neurotransmission while producing sedative effects through histamine antagonism.

Side Effects

Mirtazapine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Sedation or drowsiness: feeling unusually sleepy.
  • Increased appetite and weight gain: heightened hunger leading to weight increase.
  • Dry mouth: reduced salivation.
  • Constipation: difficulty passing stools.
  • Dizziness: sensation of light‑headedness.
  • Edema: mild swelling of extremities.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Severe hypersensitivity: rash, swelling, or anaphylaxis.
  • Suicidal thoughts: emergence or worsening of suicidal ideation.
  • Hepatotoxicity: liver enzyme abnormalities.
  • Seizures: occurrence of convulsive episodes.
  • Serotonin syndrome: signs of excessive serotonergic activity.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient history and monitor for specific risks.

  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Breastfeeding: unknown excretion; consider alternatives.
  • Elderly: start low, monitor for sedation and falls.
  • Hepatic impairment: dose adjustment may be required.
  • Concomitant CNS depressants: increase risk of excessive sedation.
  • Store at ambient temperature: keep below 25 °C, retain original packaging, protect from moisture.

Avoid Interactions

Mirtazapine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis and serotonin syndrome.
  • Potent CYP1A2 inhibitors (e.g., fluvoxamine): may raise mirtazapine plasma levels.
  • CNS depressants (e.g., benzodiazepines, alcohol): profound sedation.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., codeine, tamoxifen): altered metabolism.
  • Anticholinergic agents: additive dry mouth and constipation.
  • QT‑prolonging drugs: potential cardiac rhythm effects.

Frequently Asked Questions

Mirtazapina Flas Cinfamed contains mirtazapine, which is prescribed to treat major depressive disorder in adult patients. It may also be considered for treatment‑resistant depression or depressive episodes accompanied by anxiety, as determined by a qualified prescriber.

Mirtazapine blocks presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and antagonizes postsynaptic 5‑HT2, 5‑HT3 and H1 receptors. This combined action enhances serotonergic and noradrenergic neurotransmission while providing a sedative effect through histamine blockade.

The appropriate dose of mirtazapine is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage decisions are made by a qualified healthcare professional and are not standardized in product literature.

Safety data for mirtazapine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from SSRIs and SNRIs by its dual antagonism of α2‑adrenergic and specific serotonin receptors. This profile often results in strong sedative and appetite‑stimulating effects, which can be advantageous for patients with insomnia or weight loss, but may be less suitable for those prone to weight gain.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Mirtazapina Flas Cinfamed is taken orally, usually once daily in the evening to take advantage of its sedative properties. The tablet should be swallowed whole with water and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include agranulocytosis, severe hypersensitivity reactions, emergence or worsening of suicidal thoughts, hepatotoxicity, seizures, and serotonin syndrome when combined with other serotonergic agents. Patients should be monitored closely for any of these events.

Mirtazapine is contraindicated in patients with known hypersensitivity to the drug or any of its excipients, and in those currently taking monoamine oxidase inhibitors. Caution is also advised for individuals with severe hepatic impairment, uncontrolled epilepsy, or a history of severe cardiac arrhythmias.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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