Product image of Mirtazapina Flas Ratiopharm (Mirtazapine) supplied by GNH India

Mirtazapina Flas Ratiopharm

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapina Flas Ratiopharm (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapina Flas Ratiopharm, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral tablet for oral use. It is indicated for the treatment of major depressive disorder in adult patients.
GNH India supplies Mirtazapina Flas Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharma S.L.U.,

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Indications & Clinical Uses

  • Mirtazapine acts within the central nervous system to alleviate depressive symptoms in the major depressive disorder therapeutic area.
  • Major depressive disorder: reduces depressive mood, improves sleep and appetite, and increases overall functioning in adults.

How It Works

  • Mirtazapine blocks central presynaptic α2‑adrenergic receptors, enhancing norepinephrine release, and antagonizes postsynaptic 5‑HT2, 5‑HT3 and H1 receptors. This combined action increases serotonergic and noradrenergic neurotransmission while reducing histamine‑mediated effects, leading to its antidepressant and anxiolytic properties.

Side Effects

Mirtazapine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness or light‑headedness
  • Peripheral edema

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Seizures
  • Severe hypotension or syncope
  • Hepatic dysfunction
  • Suicidal thoughts or behavior
  • Anaphylactic or severe allergic reactions

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Hepatic function: assess liver enzymes in patients with hepatic impairment.
  • Weight monitoring: track body weight regularly due to potential gain.
  • Suicidality: monitor for emerging suicidal thoughts, especially early in treatment.
  • Elderly patients: start at low dose and watch for excessive sedation.
  • Discontinuation: avoid abrupt cessation; taper under medical supervision.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mirtazapine can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol): potential serotonin syndrome.
  • CNS depressants (e.g., benzodiazepines, alcohol): additive sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 or CYP3A4 inhibitors (e.g., fluoxetine, ketoconazole): may increase mirtazapine plasma levels.
  • CYP inducers (e.g., carbamazepine, rifampicin): may reduce efficacy.
  • Antihistamines: may enhance anticholinergic burden.
  • Warfarin: monitor INR as mirtazapine can affect coagulation parameters.

Frequently Asked Questions

Mirtazapina Flas Ratiopharm contains the active ingredient mirtazapine, which is prescribed to treat major depressive disorder in adult patients. It helps improve mood, sleep, and appetite by modulating neurotransmitter activity in the brain.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by antagonizing postsynaptic 5‑HT2, 5‑HT3 and H1 receptors. This combined effect enhances serotonergic and noradrenergic signaling while reducing histamine‑mediated sedation, producing antidepressant and anxiolytic benefits.

The appropriate dose of Mirtazapina Flas Ratiopharm is determined by the prescribing clinician based on the individual’s clinical condition, response, and tolerability. Dosage adjustments are made according to professional guidelines and patient needs.

Safety data for mirtazapine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from SSRIs and SNRIs by its dual antagonism of α2‑adrenergic and specific serotonin receptors. This profile often results in strong sedative and appetite‑stimulating effects, which can be advantageous for patients with insomnia or weight loss, but may be less suitable for those concerned about weight gain.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Mirtazapina Flas Ratiopharm is taken orally, usually once daily in the evening with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include the potential for agranulocytosis, seizures, severe hypotension, hepatic dysfunction, and the emergence or worsening of suicidal thoughts, especially during the initial treatment period. Prompt medical attention is required if any of these events occur.

Mirtazapina Flas Ratiopharm should be avoided in patients with known hypersensitivity to mirtazapine or any excipients, those currently taking monoamine oxidase inhibitors, and individuals with uncontrolled severe cardiovascular disease without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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