Product image of Mirtazapina Flas Stada (Mirtazapine) supplied by GNH India

Mirtazapina Flas Stada

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapina Flas Stada (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapina Flas Stada, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral tablet for oral use. It is indicated for the treatment of major depressive disorder in adult patients.
GNH India supplies Mirtazapina Flas Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorio Stada, S.L.

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Indications & Clinical Uses

Mirtazapine acts on central neurotransmitter pathways to alleviate depressive symptoms.

  • Major depressive disorder: improves mood, sleep, appetite and overall functional capacity.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks postsynaptic 5‑HT2 and 5‑HT3 receptors while stimulating 5‑HT1 receptors, resulting in enhanced serotonergic transmission. It also exhibits strong H1‑receptor antagonism, contributing to its sedative properties.

Side Effects

Mirtazapine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Orthostatic hypotension

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Suicidal ideation, especially early in treatment
  • Serotonin syndrome when combined with other serotonergic agents
  • Severe hypotension or syncope
  • Allergic reactions such as rash, angioedema, or anaphylaxis
  • Hepatotoxicity or liver enzyme elevations

Precautions & Warnings

Before initiating therapy, clinicians should evaluate several safety aspects.

  • Hepatic function: assess liver enzymes in patients with liver disease
  • Weight monitoring: track body weight regularly due to potential gain
  • Suicidal risk: monitor for emergent suicidal thoughts, particularly in early weeks
  • Elderly patients: use caution because of heightened sedation and fall risk
  • Discontinuation: avoid abrupt cessation to reduce withdrawal phenomena
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mirtazapine can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis
  • Other central nervous system depressants (e.g., benzodiazepines, alcohol): additive sedation
  • Serotonergic agents (e.g., SSRIs, SNRIs, tramadol): potential serotonin syndrome

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine, quinidine): may increase mirtazapine plasma levels
  • Antihistamines: enhanced anticholinergic effects
  • Antihypertensives: possible additive blood pressure lowering
  • Oral contraceptives: may reduce contraceptive effectiveness

Frequently Asked Questions

Mirtazapina Flas Stada contains mirtazapine, which is prescribed to treat major depressive disorder in adult patients. It helps improve mood, sleep quality, appetite, and overall functional ability by modulating norepinephrine and serotonin pathways.

Mirtazapine blocks presynaptic α2‑adrenergic receptors, leading to increased release of norepinephrine and serotonin. It also antagonizes postsynaptic 5‑HT2 and 5‑HT3 receptors while enhancing 5‑HT1 activity, and blocks H1 receptors, producing its antidepressant and sedative effects.

The appropriate dose of Mirtazapina Flas Stada is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and tolerability. Dosage adjustments are made according to clinical judgment.

Mirtazapina Flas Stada is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but lacking well‑controlled human data. Use only if the potential benefit justifies the potential risk. It is excreted in breast milk; breastfeeding decisions should be made with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from SSRIs and SNRIs by its dual antagonism of α2‑adrenergic and specific serotonin receptors. This profile often results in pronounced sedative and appetite‑stimulating effects, which can be advantageous for patients with insomnia or weight loss, but may be less suitable for those prone to weight gain.

Store the tablets at room temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep out of reach of children and do not use if the packaging is damaged.

Mirtazapina Flas Stada is taken orally, usually once daily in the evening due to its sedative properties. The tablet should be swallowed whole with water and not chewed or crushed unless otherwise directed by a healthcare professional.

Serious risks include agranulocytosis, severe neutropenia, suicidal thoughts or behaviors (especially early in treatment), serotonin syndrome when combined with other serotonergic drugs, and significant hypotension. Patients should be monitored closely for any of these events.

Mirtazapina Flas Stada should be avoided in patients with known hypersensitivity to mirtazapine or any excipients, those currently taking MAO inhibitors, or individuals with severe hepatic impairment without medical supervision. Caution is also advised for the elderly due to increased sedation and fall risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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