Product image of Mirtazapina Flas Viatris (Mirtazapine) supplied by GNH India

Mirtazapina Flas Viatris

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapina Flas Viatris (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapina Flas Viatris, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral dosage form for oral use. It is prescribed for the treatment of major depressive disorder in adult patients.

GNH India supplies Mirtazapina Flas Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

  • Mirtazapine is used to treat depressive disorders by modulating noradrenergic and serotonergic pathways.
  • Major depressive disorder: reduces depressive symptoms and improves mood in adults.
  • Depressive episodes in bipolar disorder (off‑label): may help alleviate depressive phases when other options are unsuitable.
  • Depression with insomnia: can improve sleep quality while treating depressive symptoms.

How It Works

  • Mirtazapine acts as an antagonist at central presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and blocks postsynaptic 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic transmission. It also antagonises histamine H1 receptors, contributing to its sedative and appetite‑stimulating effects.

Side Effects

Mirtazapine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Orthostatic hypotension

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Hepatic dysfunction
  • Severe hypersensitivity reactions (rash, angioedema)
  • Suicidal ideation or worsening depression
  • Seizures
  • Serotonin syndrome when combined with other serotonergic agents

Precautions & Warnings

  • Before prescribing mirtazapine, clinicians should consider several safety factors.
  • Liver function: assess hepatic status before initiating therapy.
  • Suicidal thoughts: monitor for worsening depression or emergence of suicidal ideation, especially early in treatment.
  • Cardiovascular disease: use caution in patients with known heart conditions due to potential orthostatic hypotension.
  • Renal impairment: adjust dose in severe renal dysfunction.
  • Discontinuation: avoid abrupt cessation; taper under medical supervision.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Mirtazapine can interact with several drug classes; some combinations should be avoided while others require careful monitoring.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol): potential serotonin syndrome.
  • CNS depressants (alcohol, benzodiazepines): additive sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 or CYP3A4 inhibitors (e.g., fluoxetine, ketoconazole): may increase mirtazapine plasma levels.
  • CYP inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • Antihypertensive drugs: possible additive blood‑pressure lowering effect.

Frequently Asked Questions

Mirtazapina Flas Viatris contains mirtazapine, which is prescribed primarily for the treatment of major depressive disorder in adult patients. It helps alleviate depressive symptoms, improve mood, and may also benefit patients who experience insomnia or loss of appetite associated with depression.

Mirtazapine increases neurotransmission by blocking presynaptic α2‑adrenergic receptors, leading to higher norepinephrine release, and by antagonising postsynaptic 5‑HT2 and 5‑HT3 receptors, which enhances serotonergic activity. Its additional H1‑receptor antagonism contributes to sedation and appetite stimulation.

The exact dose is individualized by the prescribing clinician based on the patient’s clinical condition, age, and response to therapy. Typically, treatment starts at a low dose and may be titrated upward, but the specific regimen should always follow the prescriber’s instructions.

Safety data for mirtazapine during pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Physicians usually discuss alternatives and closely monitor any pregnant or nursing patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from SSRIs and SNRIs in its receptor profile. It often causes more sedation and weight gain, which can be advantageous for patients with insomnia or poor appetite, whereas SSRIs are generally more activating and have a different side‑effect spectrum.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging. Protect it from moisture, direct sunlight, and extreme heat. Keep the container tightly closed and out of reach of children.

Mirtazapina Flas Viatris is taken orally, usually once daily in the evening to take advantage of its sedative effect. It may be swallowed with or without food; however, taking it with a light snack can reduce gastrointestinal discomfort for some patients.

The most serious risks include the emergence or worsening of suicidal thoughts, especially early in treatment, agranulocytosis or severe neutropenia, significant hepatic dysfunction, and rare cases of severe hypersensitivity or serotonin syndrome when combined with other serotonergic drugs.

Mirtazapine should be avoided in patients with known hypersensitivity to the drug, those currently taking monoamine oxidase inhibitors, or individuals with severe hepatic impairment. Caution is also advised for patients with uncontrolled cardiovascular disease or a history of seizures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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