Product image of Mirtazapina Jaba (Mirtazapine) supplied by GNH India

Mirtazapina Jaba

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapina Jaba (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapina Jaba, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral dosage form for oral use. It modulates neurotransmitter activity to alleviate depressive symptoms and is approved for adult patients with major depressive disorder.

GNH India supplies Mirtazapina Jaba as a licensed, GDP‑compliant international pharmaceutical product serving hospitals, pharmacies and clinics worldwide, with established quality‑assured manufacturing and distribution networks that meet European regulatory standards. The company ensures batch‑to‑batch consistency and provides comprehensive documentation for regulatory submissions.

Manufacturer / TM Owner

Jaba Recordati, S.A.

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Indications & Clinical Uses

Mirtazapine is a NaSSA antidepressant that acts on neurotransmitter pathways involved in mood regulation.

  • Major depressive disorder: reduces depressive symptoms and improves mood in adult patients.
  • Depressive episodes in bipolar disorder (adjunct): may be used as an add‑on therapy to manage depressive phases.
  • Anxiety symptoms associated with depression: can help lessen anxiety and improve overall well‑being.

How It Works

  • Mirtazapine works by antagonizing central presynaptic α2‑adrenergic receptors, which increases the release of norepinephrine and serotonin. It also blocks postsynaptic 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic transmission while reducing stimulation of receptors linked to anxiety and nausea. This combined action restores neurotransmitter balance, contributing to its antidepressant effect.

Side Effects

Mirtazapine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Sedation or drowsiness: feeling unusually sleepy, especially at treatment start.
  • Increased appetite and weight gain: heightened hunger leading to weight increase.
  • Dry mouth: reduced salivation causing oral dryness.
  • Constipation: slowed gastrointestinal motility.
  • Dizziness: light‑headed sensation upon standing.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Severe neutropenia: markedly low neutrophil count.
  • Hepatotoxicity: liver injury indicated by abnormal enzymes.
  • Suicidal thoughts: emergence or worsening of suicidal ideation.
  • Hypersensitivity reactions: rash, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing mirtazapine, clinicians should observe several safety considerations.

  • Assess psychiatric history: evaluate risk of suicidal thoughts before initiating therapy.
  • Monitor weight and metabolic parameters: track changes in appetite and body mass.
  • Use caution in hepatic impairment: adjust use if liver function is compromised.
  • Avoid abrupt discontinuation: taper dose to reduce withdrawal symptoms.
  • Review concomitant CNS depressants: consider additive sedation with other sedatives.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture.

Avoid Interactions

Mirtazapine can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome; avoid concurrent use.
  • Strong CYP1A2 inhibitors: may increase mirtazapine plasma levels, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., carbamazepine): may reduce mirtazapine concentrations, decreasing effectiveness.
  • CNS depressants (e.g., benzodiazepines, alcohol): can enhance sedation and respiratory depression.
  • Anticholinergic agents: may worsen dry mouth and constipation.

Frequently Asked Questions

Mirtazapina Jaba contains the antidepressant mirtazapine. It is prescribed to treat major depressive disorder in adult patients, helping to improve mood, sleep, and appetite. The medication may also be used off‑label for associated anxiety symptoms, but its primary, approved indication is the management of depressive episodes.

Mirtazapine acts as an antagonist at central presynaptic α2‑adrenergic receptors, which boosts the release of norepinephrine and serotonin. It also blocks postsynaptic 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic activity while reducing stimulation of receptors linked to anxiety and nausea. This dual action helps restore neurotransmitter balance associated with depression.

The appropriate dose of Mirtazapina Jaba is determined individually by a qualified prescriber based on the patient’s clinical condition, response, and tolerability. Dosage may be started at a low level and adjusted gradually. Patients should follow the exact regimen provided in their prescription and not alter the dose without medical advice.

The safety of mirtazapine in pregnancy and lactation has not been definitively established, and it is classified as a pregnancy category with unknown risk. Healthcare providers must weigh potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives and monitoring strategies with their doctor.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Mirtazapina Jaba. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details, and assists with any necessary import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), mirtazapine has a distinct mechanism that often produces sedation and increased appetite, which can be advantageous for patients with insomnia or weight loss. It may have fewer sexual side effects but a higher likelihood of weight gain. Choice of therapy depends on individual symptom profile, tolerability, and clinician judgment.

Mirtazapina Jaba should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date. No special refrigeration is required for this oral formulation.

The medication is taken orally, usually once daily in the evening to take advantage of its sedative effect. Tablets should be swallowed whole with a glass of water and not chewed or crushed unless otherwise directed by a healthcare professional. Patients should follow the dosing schedule prescribed by their clinician.

The most serious risks include the potential for suicidal thoughts or behavior, especially when treatment is initiated or dosages are changed. Rare but severe reactions such as agranulocytosis, severe neutropenia, and hepatotoxicity may also occur. Prompt medical attention is required if signs of infection, liver dysfunction, or worsening mood arise.

Mirtazapina Jaba is contraindicated in patients with known hypersensitivity to mirtazapine or any of its excipients. It should also be avoided in individuals currently taking monoamine oxidase inhibitors or those who have experienced severe adverse reactions to similar antidepressants. Clinicians must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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