Product image of Mirtazapina Psidep 15 Mg Comprimidos Revestidos (Mirtazapine) supplied by GNH India

Mirtazapina Psidep 15 Mg Comprimidos Revestidos

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapina Psidep 15 Mg Comprimidos Revestidos (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapina Psidep 15 Mg Comprimidos Revestidos, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as a 15 mg coated tablet for oral use. It treats major depressive disorder in adult patients.

GNH India supplies Mirtazapina Psidep 15 Mg Comprimidos Revestidos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Laboratórios Atral, S.A.

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Indications & Clinical Uses

Mirtazapine is indicated for depressive disorders, acting on noradrenergic and serotonergic pathways.

  • Major depressive disorder: reduces depressive symptoms and improves overall mood in adults.
  • Depressive episodes with anxiety features: alleviates both mood and anxiety symptoms, supporting functional recovery.

How It Works

  • Mirtazapine blocks central presynaptic α2‑adrenergic receptors, increasing the release of norepinephrine and serotonin. It also antagonizes postsynaptic 5‑HT2 and 5‑HT3 receptors while sparing 5‑HT1A, which enhances serotonergic transmission without stimulating these subtypes. The combined effect results in heightened noradrenergic and serotonergic activity, contributing to its antidepressant properties.

Side Effects

Mirtazapine may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Peripheral edema

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Aseptic meningitis
  • Hepatotoxicity
  • Emergence of suicidal thoughts, especially early in treatment
  • Severe hypotension or cardiac arrhythmia

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Assess psychiatric history: evaluate for suicidal ideation prior to treatment.
  • Monitor weight: patients may experience significant weight gain.
  • Check liver function: use caution in hepatic impairment.
  • Avoid abrupt discontinuation: taper dose to reduce withdrawal symptoms.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original packaging.

Avoid Interactions

Mirtazapine can interact with other medicines; awareness of major and moderate interactions helps ensure safe use.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis or serotonin syndrome.
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase mirtazapine plasma concentrations.
  • CNS depressants (e.g., benzodiazepines, alcohol): additive sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Other serotonergic agents (e.g., SSRIs, SNRIs): potential for serotonin syndrome.
  • Potent CYP3A4 inducers (e.g., rifampicin, carbamazepine): may lower mirtazapine exposure.

Frequently Asked Questions

Mirtazapina Psidep 15 Mg Comprimidos Revestidos contains mirtazapine, which is prescribed to treat major depressive disorder in adult patients. It helps alleviate depressive symptoms and improve overall mood as part of a comprehensive psychiatric care plan.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases the release of norepinephrine and serotonin. It also antagonizes postsynaptic 5‑HT2 and 5‑HT3 receptors while sparing 5‑HT1A, resulting in enhanced noradrenergic and serotonergic neurotransmission that contributes to its antidepressant effect.

The appropriate dose is determined by the prescribing clinician based on the individual’s clinical condition. In practice, clinicians often start with a 15 mg oral tablet taken once daily and may adjust the dose upward or downward according to therapeutic response and tolerability.

Safety data for mirtazapine during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapine belongs to the NaSSA class, whereas many other antidepressants are selective serotonin reuptake inhibitors (SSRIs). Compared with SSRIs, mirtazapine often causes more sedation and weight gain but may be preferred when patients experience insomnia or poor appetite. Both classes are effective for depression, and the choice depends on individual symptom profile and tolerability.

Mirtazapina Psidep 15 Mg Comprimidos Revestidos should be stored at ambient temperature, below 25 °C, in the original blister pack. Protect the tablets from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf life.

The tablets are taken orally, usually once daily in the evening or as directed by a healthcare professional. They should be swallowed whole with water and not crushed or chewed unless otherwise advised by a prescriber.

Serious risks include the emergence of suicidal thoughts, especially during the initial treatment period, severe neutropenia or agranulocytosis, and rare skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of infection, unexplained fever, severe rash, or worsening mood.

Mirtazapine is contraindicated in individuals who have taken a monoamine oxidase inhibitor within the past 14 days, as well as those with known hypersensitivity to the drug. Caution is also advised for patients with severe hepatic impairment, uncontrolled epilepsy, or a history of bipolar disorder with manic episodes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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