Product image of Mirtazapina Teva (Mirtazapine) supplied by GNH India

Mirtazapina Teva

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapina Teva (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapina Teva, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral tablet for oral use. It works by modulating central neurotransmitters and is indicated for the management of major depressive disorder in adult patients, helping to improve mood, sleep and appetite.

GNH India supplies Mirtazapina Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing and regulatory support for global healthcare providers and ensuring product quality throughout the supply chain.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Mirtazapine is used to treat depressive disorders by influencing serotonergic and noradrenergic pathways.
  • Major depressive disorder (acute): reduces core depressive symptoms and improves overall mood.
  • Major depressive disorder (maintenance): helps prevent relapse after initial response.
  • Depressive symptoms with insomnia: promotes sleep and appetite normalization.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks 5‑HT2 and 5‑HT3 receptors while also inhibiting H1 histamine receptors. This combined action enhances serotonergic and noradrenergic neurotransmission, contributing to its antidepressant and anxiolytic effects.

Side Effects

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Fatigue

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Severe hypotension or syncope
  • Seizures
  • Suicidal ideation or behavior
  • Hepatic dysfunction
  • Blood dyscrasias such as thrombocytopenia

Precautions & Warnings

Mirtazapine should be used with caution in several clinical situations.

  • Assess cardiovascular status: monitor for orthostatic hypotension, especially in the elderly.
  • Evaluate hepatic function: dose adjustment may be required in patients with liver impairment.
  • Screen for suicidal thoughts: heightened risk during early treatment phases.
  • Avoid abrupt discontinuation: taper gradually under medical supervision to prevent withdrawal symptoms.
  • Caution in elderly: increased sensitivity to sedation and anticholinergic effects.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mirtazapine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • CNS depressants (e.g., benzodiazepines, opioids): enhanced sedation and respiratory depression.
  • Strong CYP2D6 inhibitors: increased mirtazapine plasma concentrations.

Moderate Interactions (Monitor Closely)

  • SSRIs or SNRIs: potential for serotonin syndrome.
  • Anticholinergic agents: additive anticholinergic burden.
  • Alcohol: increased central nervous system depression and impaired coordination.

Frequently Asked Questions

Mirtazapina Teva contains the active ingredient mirtazapine and is prescribed for the treatment of major depressive disorder in adult patients. It helps alleviate depressive symptoms, improve sleep quality, and normalize appetite.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by antagonizing 5‑HT2, 5‑HT3 and H1 receptors. This combined effect enhances serotonergic and noradrenergic neurotransmission, contributing to its antidepressant activity.

The appropriate dose of Mirtazapina Teva is determined by the prescribing clinician based on the patient’s clinical condition, response to therapy, and tolerability. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Safety data for mirtazapine in pregnancy and lactation are limited, and the medication should only be used if the potential benefit justifies any potential risk to the fetus or infant. Consultation with a healthcare professional is essential before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from SSRIs and SNRIs by its dual antagonism of α2‑adrenergic and specific serotonin receptors. It often causes sedation and weight gain, which can be advantageous for patients with insomnia or loss of appetite, whereas other antidepressants may have different side‑effect profiles.

Mirtazapina Teva should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date.

Mirtazapina Teva is taken orally, usually once daily in the evening, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless otherwise directed by a healthcare professional.

Serious risks include agranulocytosis, severe hypotension, seizures, hepatic dysfunction, and the emergence or worsening of suicidal thoughts, particularly during the initial weeks of therapy. Patients should be monitored closely for any unusual symptoms.

Mirtazapina Teva is contraindicated in patients with known hypersensitivity to mirtazapine or any of its excipients, and in those currently taking monoamine oxidase inhibitors. Caution is advised for individuals with severe hepatic impairment, uncontrolled hypertension, or a history of bipolar disorder.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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