Product image of Mirtazapine supplied by GNH India

Mirtazapine

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapine

Mirtazapine, the active ingredient in Mirtazapine, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as a tablet for oral use. It treats major depressive disorder in adult patients.
GNH India supplies Mirtazapine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Noumed Life Sciences

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Indications & Clinical Uses

  • Mirtazapine is indicated for major depressive disorder, acting on the serotonergic and noradrenergic pathways to improve mood and functional capacity.
  • Major depressive disorder: reduces depressive symptoms and enhances overall wellbeing in adult patients.

How It Works

  • Mirtazapine blocks central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and antagonizes postsynaptic 5‑HT2 and 5‑HT3 receptors, which together augment serotonergic and noradrenergic neurotransmission while reducing serotonergic side‑effects.

Side Effects

Mirtazapine may cause a range of adverse reactions.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Peripheral edema

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Hepatic dysfunction or jaundice
  • Severe hypersensitivity reactions (e.g., Stevens‑Johnson syndrome)
  • Suicidal ideation, especially early in treatment
  • Seizures
  • Cardiovascular events such as arrhythmia

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Assess hepatic function: evaluate liver enzymes in patients with liver disease.
  • Monitor weight: watch for significant weight gain, especially in patients with metabolic risk.
  • Caution in elderly: increased sensitivity to sedation and orthostatic hypotension.
  • Avoid abrupt discontinuation: taper dose to reduce withdrawal symptoms.
  • Contraindicated with MAO inhibitors: ensure a washout period of at least 14 days.
  • Pregnancy: risk category unknown, use only if benefit outweighs risk.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Mirtazapine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis and serotonin syndrome.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol): heightened serotonin toxicity.
  • CNS depressants (e.g., benzodiazepines, alcohol): additive sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase mirtazapine plasma levels.
  • Carbamazepine: may reduce mirtazapine effectiveness.
  • Anticoagulants (e.g., warfarin): monitor INR for potential changes.
  • Antihistamines: may enhance sedative effects.
  • Alcohol: can intensify central nervous system depression.

Frequently Asked Questions

Mirtazapine is prescribed primarily for the treatment of major depressive disorder in adult patients. It helps alleviate depressive symptoms such as low mood, loss of interest, and impaired concentration by modulating serotonergic and noradrenergic neurotransmission.

Mirtazapine works by antagonizing central presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by blocking postsynaptic 5‑HT2 and 5‑HT3 receptors. This combined action enhances overall serotonergic and noradrenergic signaling while reducing certain serotonin‑related side effects.

The dosage of Mirtazapine is individualized and set by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage adjustments are made according to clinical judgment and therapeutic response.

The pregnancy safety category for Mirtazapine is unknown. It should only be used during pregnancy or lactation if the potential benefit justifies the possible risk to the fetus or infant. Consultation with a healthcare professional is essential.

To request Mirtazapine, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any required import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), Mirtazapine has a distinct mechanism that often results in greater sedation and appetite stimulation. It may be preferred when patients need help with insomnia or weight gain, but the side‑effect profile differs from other classes.

Mirtazapine tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

Mirtazapine is taken orally, usually once daily in the evening due to its sedative effect. It is available in tablet form and should be swallowed whole with water, unless otherwise directed by a healthcare professional.

Serious risks include agranulocytosis, severe hepatic dysfunction, hypersensitivity reactions such as Stevens‑Johnson syndrome, and the emergence or worsening of suicidal thoughts, particularly early in treatment. Prompt medical attention is required if any of these occur.

Mirtazapine is contraindicated in patients who have taken monoamine oxidase inhibitors (MAOIs) within the past 14 days, those with known hypersensitivity to the drug, and individuals with severe hepatic impairment where benefit does not outweigh risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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